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In view of the controversial role of catalytic activity on the cytotoxicity of phospholipase A 2 (PLA 2 ), the present study is conducted to explore whether PLA 2 induces apoptotic process of human leukemia U937 cells through catalytic activity-independent pathway. Modification of His-48 (according to the sequence alignment with porcine pancreatic PLA 2 ) with p-bromophenacyl...
Modification of catalytic residue His-47 with p-bromophenacyl bromide (BPB) abolished the enzymatic activity of Naja naja atra phospholipase A 2 (PLA 2 ). Additionally, alterations in the global structure and the spatial positions of Trp residues were noted in His-modified PLA 2 . The cell viability of human neuroblastoma SK-N-SH cells was decreased by approximately 40% and...
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