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The objective of this study was to test the hypothesis that 4 weeks of lithium administration would be associated with changes in brain gray and white matter volumes in healthy individuals. Thirteen right-handed healthy volunteers (6 females, mean age=25.9±10.0 years) were studied. 3D SPGR MRIs (TR=25ms, TE=5ms, slice-thickness=1.5mm) were acquired using a 1.5 T GE Signa Imaging System, at baseline...
The neurobiological underpinnings of bipolar disorder are not well understood. Previous neuroimaging findings have been inconsistent; however, new methods for three-dimensional (3-D) computational image analysis may better characterize neuroanatomic changes than standard volumetric measures.We used high-resolution magnetic resonance imaging and cortical pattern matching methods to map gray matter...
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