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The stromal compartment of the normal breast microenvironment is abundant in adipose progenitor cells. These cells experience differential mechanical cues during mammary tumorigenesis; however, it is largely unknown whether tumor-mediated reduction in extracellular matrix (ECM) compliance alters the behavior of adipose progenitor cells. To investigate this possible relationship we have developed an...
The purpose of this study was to evaluate cyclooxygenase-2 (COX-2) expression in the successive steps of breast carcinogenesis and to determine its correlation with HER-2/neu and p53 expression in invasive ductal carcinomas of the breast. Immunohistochemical staining with anti-COX-2 antibody was performed in normal breast tissue, usual hyperplasia, ductal carcinoma in situ, and invasive ductal carcinoma...
Pseudoangiomatous stromal hyperplasia (PASH) of the breast is characterized by interanastomosing slit-like spaces lined with spindle-shaped cells in an abundant fibrous stroma. PASH is a relatively common incidental finding in the breast tissue removed for other reasons and rarely presents as a localized mass. The etiology of PASH is unknown, but hormonal factors are thought to be involved. Accessory...
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