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It has been recognized that phospholipase A 2 (PLA 2 ) is a crucial factor of snake venom induced inflammation. Recently, promutoxin, a novel member of minor subgroup of snake venom PLA 2 (R49 PLA 2 ) has been characterized in our laboratory, but its roles in induction of inflammation remain uninvestigated. Using highly purified promutoxin, we found this enzymatically...
Poisonous snakebite wound is a popular disease worldwide. However, the pathogenesis remains unclear. In the present study, a novel metalloproteinase atrahagin in Chinese cobra (Naja atra) snake venom was purified, using heparin–sepharose followed by Superdex 75 gel filtration chromatography. Apart from its α-fibrinogenase activity, atrahagin potently activated human colon, lung and tonsil mast cells...
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