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Signal transduction through cAMP to activate gene expression via the cAMP-responsive element (CRE) is one of the most intensively studied transcription pathways. In this pathway, transcription factor CRE-binding protein (CREB) recognizes the CRE enhancer on DNA. The CREB protein is activated via phosphorylation at serine 133 by protein kinase A and then is able to recruit coactivator CREB-binding...
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