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Some mouse models of Down syndrome (DS), including Ts1Cje mice, exhibit impaired prenatal neurogenesis with yet unknown molecular mechanism. To gain insights into the impaired neurogenesis, a transcriptomic and flow cytometry analysis of E14.5 Ts1Cje embryo brain was performed. Our analysis revealed that the neutrophil and monocyte ratios in the CD45‐positive hematopoietic cells were relatively increased,...
Résumé Introduction — problèmes conceptuels L’information à donner aux futurs parents avant les tests de calcul de risque pour la trisomie 21 est très complexe, en raison notamment de la rapidité avec laquelle le dépistage s’est mis en place, de la difficulté à gérer les faux-négatifs, les fauxpositifs et les fausses couches induites. S’ajoute à cela qu’un dépistage implicite se fait inévitablement...
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