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The effects of tamoxifen and 5-fluorouracil (5-FU) on the patterns of argyrophilic nucleolar organizer regions (AgNORs) in MCF7 human breast cancer cells were studied. Tamoxifen and 5-FU both inhibited the growth of MCF-7 cells by 18% by day 3 of culture, but each had different effects on the AgNORs. Whereas no significant changes were induced by tamoxifen, effects on the AgNORs of MCF-7 cells by...
Nocturnal infusion of 5-fluorouracil (FUra) was performed in nine patients with disseminated cancer. Three gastric, three colon and three breast cancer patients were administered 300 mg/m 2 FUra continuously for 10 h per day from 2100 h to 0700 h for more than 20 consecutive days. In the first three patients, who were treated by drip infusion without the use of a volumetric pump, serum FUra...
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