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Self‐assembled amphiphilic peptide units and supercoiled, circular double‐stranded plasmid DNA are used as building blocks to form peptide/DNA fibers for virus encapsulation. Since the fiber formation process takes place under ambient conditions and is aqueous‐based without the use of denaturing organic solvents, the bioactivity of viruses is well preserved.
Nonviral magnetofection facilitates gene transfer by using a magnetic field to concentrate magnetic nanoparticle-associated plasmid delivery vectors onto target cells. In light of the well-established effects of the Tat peptide, a cationic cell-penetrating peptide, that enhances the cytoplasmic delivery of a variety of cargos, we tested whether the combined use of magnetofection and Tat-mediated intracellular...
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