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Post-translational modifications i.e. phosphorylation and acetylation are pivotal requirements for proper functioning of eukaryotic proteins. The current study aimed to decode the impact of acetylation/deacetylation of non-histone targets i.e. FoxO1/3a and p53 of sirtuins (NAD+ dependent enzymes with lysine deacetylase activity) in berberine treated human hepatoma cells. Berberine (100μM) inhibited...
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