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We investigated whether protein kinase P38 plays a role in the brain-aging changes associated with repeated ethanol withdrawal (EW). Ovariectomized young, middle-age and older rats, with or without 17β-estradiol (E2) implantation, received a 90-day ethanol with repeated withdrawal. They were tested for active pP38 expression in cerebellar Purkinje neurons and whole-cerebellar lysates using immunohistochemistry...
Parvalbumin (PA) is a calcium-binding protein that has been implicated in neuroprotection. We examined whether the stimulus effect of ethanol withdrawal (EW) alters the expression of PA in a manner that is prevented by 17β-estradiol (E2). Ovariectomized rats implanted with E2 (EW/E2) or oil (EW/Oil) pellets received chronic ethanol (7.5%, w/v, 5 weeks) or control dextrin diets (Dex/Oil). At 24h of...
Results of studies from our laboratory have shown that administration of 17β-estradiol (E 2 ) reduces cerebellar neuronal damage during ethanol withdrawal (EW). In the current study, we investigated whether the GABAergic system is involved in the protective effects of E 2 against the EW syndrome. To test this hypothesis, we examined the effects of GABAergic drugs, with and without...
Results of studies from our laboratory have shown that administration of 17β-estradiol (E 2 ) reduces cerebellar neuronal damage during ethanol withdrawal (EW). In the current study, we examined mechanisms underlying E 2 protection against EW-associated cerebellar damage by assessing apoptotic indicators: DNA fragmentation, caspase-3 activity, and protein kinase C (PKC) activity. Ovariectomized...
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