Search results for: Qun Lin

Items from 1 to 20 out of 148 results

article

Efficacy and safety of eculizumab in Guillain‐Barré syndrome: A phase 3, multicenter, double‐blind, randomized, placebo‐controlled clinical trial

Satoshi Kuwabara, Susumu Kusunoki, Motoi Kuwahara, Yoshihisa Yamano, more

Journal of the Peripheral Nervous System > 29 > 3 > 339 - 349

Background and Aims Guillain‐Barré syndrome (GBS) is an acute, self‐limited, immune‐mediated peripheral neuropathy. Current treatments for GBS include intravenous immunoglobulin (IVIg) and plasma exchange, which may not sufficiently benefit severely affected patients. This study evaluated the efficacy and safety of eculizumab add‐on therapy to IVIg (standard‐of‐care treatment) in patients with severe...

article

The impact of breast‐conserving surgery and modified radical mastectomy on postoperative wound complications in patients with early breast cancer

Xiaopeng Yang, Qun Lin, Qunfei Wang

International Wound Journal > 21 > 2 > n/a - n/a

In recent years, breast conservation surgery (BCS) and modified radical mastectomy (MRM) have been widely used in the treatment of early‐stage breast cancer. However, the effects of complications from these two surgical methods are still unclear. The purpose of this study was to evaluate the effects of BCS and MRM on postoperative wound complications in patients with early breast cancer. Eighty‐eight...

article

CD39 pathway inhibits Th1 cell function in tuberculosis

Ying Luo, Ying Xue, Qun Lin, Guoxing Tang, more

Immunology > 166 > 4 > 522 - 538

The role of CD39 pathway in Th1 cell function in tuberculosis (TB) is rarely elucidated. The present study aims to investigate the modulating mechanism of CD39 pathway during Mycobacterium tuberculosis (MTB) infection. CD39 expression was examined on host immune cells among patients with TB. The relationship between CD39 expression and Th1 cell function was analysed. Patients with TB displayed dramatically...

article

Reproducibility in the absence of selective reporting: An illustration from large‐scale brain asymmetry research

Xiang‐Zhen Kong, ENIGMA Laterality Working Group, Clyde Francks, Xiang‐Zhen Kong, more

Human Brain Mapping > 43 > 1 > 244 - 254

The problem of poor reproducibility of scientific findings has received much attention over recent years, in a variety of fields including psychology and neuroscience. The problem has been partly attributed to publication bias and unwanted practices such as p‐hacking. Low statistical power in individual studies is also understood to be an important factor. In a recent multisite collaborative study,...

article

Combination of prealbumin and tuberculosis‐specific antigen/phytohemagglutinin ratio for discriminating active tuberculosis from latent tuberculosis infection

Ying Luo, Ying Xue, Xu Yuan, Qun Lin, more

International Journal of Clinical Practice > 75 > 4 > n/a - n/a

Background Given that there is no rapid and effective method for distinguishing active tuberculosis (ATB) from latent tuberculosis infection (LTBI), the discrimination between these two statuses remains challenging. This study sought to investigate the value of nutritional indexes and tuberculosis‐specific antigen/phytohemagglutinin ratio (TBAg/PHA ratio) for distinguishing ATB from LTBI. Methods...

article

The substrate‐dependent regulatory effects of the AfeI/R system in Acidithiobacillus ferrooxidans reveals the novel regulation strategy of quorum sensing in acidophiles

Xue‐Yan Gao, Chang‐Ai Fu, Likai Hao, Xiu‐Feng Gu, more

Environmental Microbiology > 23 > 2 > 757 - 773

A LuxI/R‐like quorum sensing (QS) system (AfeI/R) has been reported in the acidophilic and chemoautotrophic Acidithiobacillus spp. However, the function of AfeI/R remains unclear because of the difficulties in the genetic manipulation of these bacteria. Here, we constructed different afeI mutants of the sulfur‐ and iron‐oxidizer A. ferrooxidans, identified the N‐acyl homoserine lactones (acyl‐HSLs)...

article

Generation of a hypoxia‐sensing mouse model

Qun Lin, Yan Huang, Frank J. Giordano, Zhong Yun

genesis > 58 > 3-4 > n/a - n/a

Oxygen (O₂) homeostasis is essential to the metazoan life. O₂‐sensing or hypoxia‐regulated molecular pathways are intimately involved in a wide range of critical cellular functions and cell survival from embryogenesis to adulthood. In this report, we have designed an innovative hypoxia sensor (O₂CreER) based on the O₂‐dependent degradation domain of the hypoxia‐inducible factor‐1α and Cre recombinase...

article

Cover Image, Volume 58, Issue 3‐4

Qun Lin, Yan Huang, Frank J. Giordano, Zhong Yun

genesis > 58 > 3-4 > n/a - n/a

Cover illustration: The back cover image is based on the Short Communication Generation of a hypoxia‐sensing mouse model by Zhong Yun, Qun Lin, Frank, J. Giordano et al., https://doi.org/10.1002/dvg.23352.

article

Epidemiology of Clostridium difficile infection in hospitalized adults and the first isolation of C. difficile PCR ribotype 027 in central China

Yu Zhou, Liyan Mao, Jing Yu, Qun Lin, more

BMC Infectious Diseases > 2019 > 19 > 1 > 1-14

Background Clostridium difficile infection (CDI) is an emerging healthcare problem in the world. The purpose of this study was to perform a systematic epidemiological research of CDI in Tongji hospital, the central of China. Methods Stool samples from hospitalized adults suspected of CDI were enrolled. The diagnosis of CDI were based on the combination of clinical symptoms and laboratory results...

article

The hypoxic tumor microenvironment in vivo selects tumor cells with increased survival against genotoxic stresses

Hoon Kim, Qun Lin, Zhong Yun

Cancer Letters > 2018 > 431 > C > 142-149

Tumor sensitivity to radiation therapy has been known to be dependent on O₂ concentrations. However, radiosensitivity of naturally occurring hypoxic tumor cells remains to be well fully investigated in direct comparison to that of their adjacent non-hypoxic tumor cells within the same tumor. We developed a hypoxia-sensing xenograft model using the hypoxia-response element (HRE)-driven enhanced green...

article

Helcococcus ovis in a patient with an artificial eye: a case report and literature review

Liyan Mao, Zhongju Chen, Yanfang Lu, Jing Yu, more

BMC Infectious Diseases > 2018 > 18 > 1 > 1-8

Background Helcococcus ovis, belonging to the genus of Helcococcu in Peptostreptococcaceae, is one kind of facultative anaerobic and gram-positive cocci, which was first isolated from a mixed infection in sheep in 1999. To our knowledge, it’s known as an invasive pathogen in animals, and never been reported as a human pathogen in published literature. The aims of this work are to describe the first...

article

Effects of fundamental nutrient stresses on the lipid accumulation profiles in two diatom species Thalassiosira weissflogii and Chaetoceros muelleri

Qun Lin, Wen-Hao Zhuo, Xin-Wei Wang, Chang-Ping Chen, more

Bioprocess and Biosystems Engineering > 2018 > 41 > 8 > 1213-1224

Microalgae are considered as attractive feedstocks for biofuel production nowadays because of their high lipid contents and easy cultivation. In the present study, two diatoms, Thalassiosira weissflogii and Chaetoceros muelleri, were cultured under various nutrient-limitation conditions to explore their comprehensive lipid accumulation profiles for further commercialization. In T. weissflogii, the...

article

Colorimetric and fluorescent dual-mode sensing of alkaline phosphatase activity in L-02 cells and its application in living cell imaging based on in-situ growth of silver nanoparticles on graphene quantum dots

Hai-Feng Lu, Miao-Miao Zhang, Dan Wu, Jian-Liu Huang, more

Sensors and Actuators B: Chemical > 2018 > 258 > C > 461-469

Herein we report a new colorimetric and fluorescent dual-mode sensor for alkaline phosphatase (ALP) activity based on the specific enzyme amplification of ALP and the unique optical properties of graphene quantum dots (GQDs)/silver nanoparticles (AgNPs) hybrid. In this strategy, ALP enabled the removal of phosphate group from ascorbic acid 2-phosphate to yield ascorbic acid. Silver ions could be attached...

article

The hypoxic tumor microenvironment in vivo selects the cancer stem cell fate of breast cancer cells

Hoon Kim, Qun Lin, Peter M. Glazer, Zhong Yun

Breast Cancer Research > 2018 > 20 > 1 > 1-15

Background Tumor hypoxia is an independent prognostic factor associated with poor patient survival. Emerging evidence suggests that hypoxia can potentially maintain or enhance the stem cell phenotype of both normal stem cells and cancer cells. However, it remains to be determined whether cell fate is regulated in vivo by the hypoxic tumor microenvironment (TME). Methods We established a hypoxia-sensing...

article

Application of 3D–DSA simulated surgical path in intracranial aneurysm clipping surgery

Jun Sun, Zhiwei Li, Chuan Lu, Xiandong Chen, more

Chinese Neurosurgical Journal > 2017 > 3 > 1 > 1-4

Background Intracranial aneurysm is a common cerebrovascular disease, which cause wide concern by neurosurgeons. The 3D–DSA images simulated surgical path may improve the success rate of operation in bridging surgery of emergency ruptured intracranial aneurysms. Methods Eighteen patients with intracranial ruptured aneurysms that underwent craniotomy clipping surgery from January 2015 to January...

article

Study on the excision and integration mediated by class 1 integron in Streptococcus pneumoniae

Qun Lin, Pusheng Xu, Jiaowu Li, Jinhua Huang, more

Microbial Pathogenesis > 2017 > 111 > C > 446-449

As a novel antibiotic resistance mobile element, integron was recognized as a primary source of antibiotic genes among Gram-positive organisms for its excision and integration of exogenous genes. In this study, Streptococcus pneumoniae was subjected to investigate the excision and integration of class 1 integron with eight different plasmids. As the results indicated, excision in both att site and...

article

Macrophage migration inhibitory factor levels in serum from patients with acute intracerebral hemorrhage: Potential contribution to prognosis

Qun Lin, Jian-Yong Cai, Chuan Lu, Jun Sun, more

Clinica Chimica Acta > 2017 > 472 > C > 58-63

Intracerebral hemorrhage (ICH) pathophysiology involves inflammation. Macrophage migration inhibition factor (MIF), a pro-inflammatory cytokine, is related to prognosis of ischemic stroke. The aim of this study was to investigate whether serum MIF levels are associated with severity and outcomes in patients with acute ICH.We enrolled a total of 120 consecutive ICH patients and 120 healthy controls...

article

Prevention of type 2 diabetes with the traditional Chinese patent medicine: A systematic review and meta-analysis

Bing Pang, Feng-mei Lian, Xi-yan Zhao, Xue-min Zhao, more

Diabetes Research and Clinical Practice > 2017 > 131 > C > 242-259

Early interventions in prediabetes can prevent or delay the incidence of type 2 diabetes mellitus (T₂DM). The aim of this review was to assess the efficacy and safety of traditional Chinese patent medicine (TCPM) on the prevention of T₂DM.Seven electronic databases were searched to identify eligible trials published until June 1, 2016. Randomized controlled trials (RCTs) that compared TCPM plus lifestyle...

article

Direct bacterial loop-mediated isothermal amplification detection on the pathogenic features of the nosocomial pathogen – Methicillin resistant Staphylococcus aureus strains with respiratory origins

Qun Lin, Pusheng Xu, Jiaowu Li, Yin Chen, more

Microbial Pathogenesis > 2017 > 109 > C > 183-188

Loop-mediated isothermal amplification based detection assays using bacterial culture or colony for direct detection of methicillin resistant Staphylococcus aureus(MRSA) had been developed and evaluated, followed by its extensive application on a large scale of clinical MRSA isolated from respiratory origins, including nasal swabs and sputums. Six primers, including outer primers, inner primers and...

article

Effect of modified iodine on defect structure and antibacterial properties of ZnO in visible light

Qian-Ying Lin, Qun Lin, Yi-Qiu Zhang, Hua-Xiang Lin, more

Research on Chemical Intermediates > 2017 > 43 > 9 > 5067-5081

Iodine-modified ZnO with oxygen vacancies were synthesized by the solvothermal method. The crystal structure, morphology, optical properties and defects of as-prepared samples were characterized by XRD, SEM, DRS, XPS and ESR. The photocatalytic disinfection activity of I-modified ZnO in the dark and under visible light irradiation were investigated by the antibacterial drop-test method. The results...

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INFONA - science communication portal

Search results for: Qun Lin

Efficacy and safety of eculizumab in Guillain‐Barré syndrome: A phase 3, multicenter, double‐blind, randomized, placebo‐controlled clinical trial

The impact of breast‐conserving surgery and modified radical mastectomy on postoperative wound complications in patients with early breast cancer

CD39 pathway inhibits Th1 cell function in tuberculosis

Reproducibility in the absence of selective reporting: An illustration from large‐scale brain asymmetry research

Combination of prealbumin and tuberculosis‐specific antigen/phytohemagglutinin ratio for discriminating active tuberculosis from latent tuberculosis infection

The substrate‐dependent regulatory effects of the AfeI/R system in Acidithiobacillus ferrooxidans reveals the novel regulation strategy of quorum sensing in acidophiles

Generation of a hypoxia‐sensing mouse model

Cover Image, Volume 58, Issue 3‐4

Epidemiology of Clostridium difficile infection in hospitalized adults and the first isolation of C. difficile PCR ribotype 027 in central China

The hypoxic tumor microenvironment in vivo selects tumor cells with increased survival against genotoxic stresses

Helcococcus ovis in a patient with an artificial eye: a case report and literature review

Effects of fundamental nutrient stresses on the lipid accumulation profiles in two diatom species Thalassiosira weissflogii and Chaetoceros muelleri

Colorimetric and fluorescent dual-mode sensing of alkaline phosphatase activity in L-02 cells and its application in living cell imaging based on in-situ growth of silver nanoparticles on graphene quantum dots

The hypoxic tumor microenvironment in vivo selects the cancer stem cell fate of breast cancer cells

Application of 3D–DSA simulated surgical path in intracranial aneurysm clipping surgery

Study on the excision and integration mediated by class 1 integron in Streptococcus pneumoniae

Macrophage migration inhibitory factor levels in serum from patients with acute intracerebral hemorrhage: Potential contribution to prognosis

Prevention of type 2 diabetes with the traditional Chinese patent medicine: A systematic review and meta-analysis

Direct bacterial loop-mediated isothermal amplification detection on the pathogenic features of the nosocomial pathogen – Methicillin resistant Staphylococcus aureus strains with respiratory origins

Effect of modified iodine on defect structure and antibacterial properties of ZnO in visible light

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