Search results for: Michael R. Bristow

Items from 1 to 20 out of 145 results

article

The effect of cardiac resynchronization without a defibrillator on morbidity and mortality: an individual patient data meta‐analysis of COMPANION and CARE‐HF

John G.F. Cleland, Michael R. Bristow, Nicholas Freemantle, Brian Olshansky, more

European Journal of Heart Failure > 24 > 6 > 1080 - 1090

Aims Cardiac resynchronization therapy (CRT) reduces morbidity and mortality for patients with heart failure, reduced left ventricular ejection fraction, QRS duration >130 ms and in sinus rhythm. The aim of this study was to identify patient characteristics that predict the effect, specifically, of CRT pacemakers (CRT‐P) on all‐cause mortality or the composite of hospitalization for heart failure...

article

Transcriptome analysis of human heart failure reveals dysregulated cell adhesion in dilated cardiomyopathy and activated immune pathways in ischemic heart failure

Mary E. Sweet, Andrea Cocciolo, Dobromir Slavov, Kenneth L. Jones, more

BMC Genomics > 2018 > 19 > 1 > 1-14

Background Current heart failure (HF) treatment is based on targeting symptoms and left ventricle dysfunction severity, relying on a common HF pathway paradigm to justify common treatments for HF patients. This common strategy may belie an incomplete understanding of heterogeneous underlying mechanisms and could be a barrier to more precise treatments. We hypothesized we could use RNA-sequencing (RNA-seq)...

article

A genotype-directed comparative effectiveness trial of Bucindolol and metoprolol succinate for prevention of symptomatic atrial fibrillation/atrial flutter in patients with heart failure: Rationale and design of the GENETIC-AF trial

Jonathan P. Piccini, Stuart J. Connolly, William T. Abraham, Jeff S. Healey, more

American Heart Journal > 2018 > 199 > C > 51-58

Few therapies are available for the safe and effective treatment of atrial fibrillation (AF) in patients with heart failure. Bucindolol is a non-selective beta-blocker with mild vasodilator activity previously found to have accentuated antiarrhythmic effects and increased efficacy for preventing heart failure events in patients homozygous for the major allele of the ADRB1 Arg389Gly polymorphism (ADRB1...

article

Contractile reserve and the response to cardiac resynchronization therapy

Michael R. Bristow

International Journal of Cardiology > 2018 > 252 > C > 234-235

article

Improving Heart Failure Therapeutics Development in the United States

Christopher M. O’Connor, Mitchell A. Psotka, Mona Fiuzat, JoAnn Lindenfeld, more

Journal of the American College of Cardiology > 2018 > 71 > 4 > 443-453

The current heart failure clinical trial environment is strained by increasing complexity and cost, regulatory requirements, competing demands on stakeholders, implementation challenges, and decreasing patient and investigator participation. To begin the process of developing potentially effective strategies and tactics, stakeholders including patients; investigators; academic leaders; pharmaceutical...

article

Histamine H2 Receptor Polymorphisms, Myocardial Transcripts, and Heart Failure (from the Multi-Ethnic Study of Atherosclerosis and Beta-Blocker Effect on Remodeling and Gene Expression Trial)

Peter J. Leary, Richard A. Kronmal, David A. Bluemke, Peter M. Buttrick, more

The American Journal of Cardiology > 2018 > 121 > 2 > 256-261

Myocardial H₂ receptor activation contributes to heart failure (HF) in preclinical models, and H₂ receptor antagonists are associated with decreased HF incidence. This study evaluated whether H₂ histamine receptor (HRH2) single nucleotide polymorphisms (SNPs) are associated with HF incidence and whether myocardial transcript abundance is associated with HF recovery. The association of SNPs in HRH2...

article

MicroRNAs in Heart Failure, Cardiac Transplantation, and Myocardial Recovery: Biomarkers with Therapeutic Potential

Palak Shah, Michael R. Bristow, J. David Port

Current Heart Failure Reports > 2017 > 14 > 6 > 454-464

Purpose of Review Heart failure is increasing in prevalence with a lack of recently developed therapies that produce major beneficial effects on its associated mortality. MicroRNAs are small non-coding RNA molecules that regulate gene expression, are differentially regulated in heart failure, and are found in the circulation serving as a biomarker of heart failure. Recent Findings Data suggests...

article

Outcomes of cardiac resynchronization therapy in patients with intermittent atrial fibrillation or atrial flutter in the COMPANION trial

Matthew M. Kalscheur, Leslie A. Saxon, Byron K. Lee, Jonathan S. Steinberg, more

Heart Rhythm > 2017 > 14 > 6 > 858-865

Controlled clinical trial data are lacking for cardiac resynchronization therapy (CRT) outcomes in patients with advanced heart failure (HF) from reduced left ventricular ejection fraction (HFrEF) and intermittent atrial fibrillation or flutter (IAF/AFL).The purpose of this study was to describe CRT outcomes in patients with IAF/AFL and advanced HF.HF outcomes in patients in the COMPANION (Comparison...

article

Data and Safety Monitoring Board evaluation and management of a renal adverse event signal in TOPCAT

Michael R. Bristow, Kavita Sharma, Susan F. Assmann, Stuart Linas, more

European Journal of Heart Failure > 19 > 4 > 457 - 465

Clinical trial Data and Safety Monitoring Boards (DSMBs) have a primary obligation of ensuring study participant safety, while maintaining trial integrity. The role of DSMBs is expanding, and ideally should include post‐hoc reporting of deliberative processes related to clinically important safety issues or factors that could impact on future trial designs. We describe how the TOPCAT DSMB detected,...

article

Genetic variation expressed in the brain may impact heart failure

Michael R. Bristow

European Journal of Heart Failure > 19 > 3 > 324 - 325

article

Reply

Peter J. Leary, Michael R. Bristow

Journal of the American College of Cardiology > 2016 > 68 > 18 > 2029-2030

article

Histamine H2 Receptor Antagonists, Left Ventricular Morphology, and Heart Failure Risk

Peter J. Leary, Ryan J. Tedford, David A. Bluemke, Michael R. Bristow, more

Journal of the American College of Cardiology > 2016 > 67 > 13 > 1544-1552

Myocardial H₂ receptor activation may promote cardiac fibrosis and apoptosis in pre-clinical models and histamine H₂ receptor antagonist (H2RA) use may improve symptoms in participants with heart failure (HF); however, relationships between H2RA use, incident HF, and longitudinal change in left ventricular (LV) morphology are not known.This study sought to determine whether H2RA use is associated...

article

Sex-related differences in age-associated downregulation of human ventricular myocardial β1-adrenergic receptors

JoAnn Lindenfeld, Joseph C. Cleveland, David P. Kao, Michel White, more

The Journal of Heart and Lung Transplantation > 2016 > 35 > 3 > 352-361

With increasing age, human ventricular myocardium exhibits selective downregulation of β₁-adrenergic receptors (β₁-ARs). We tested the hypothesis that sex differences exist in age-related changes in β₁-ARs.Left (LV) and right (RV) ventricular tissue was obtained from 61 unplaceable potential organ donor hearts ages 1 to 71 years with no known cardiac history and from LVs removed from 56 transplant...

chapter

Thyroid Hormone Receptor Signaling in Normal and Failing Heart

Koichiro Kinugawa, Mark Y. Jeong, Michael R. Bristow, Carlin S. Long

Thyroid and Heart Failure > Basic Aspects of Thryroid Hormone and Cardiovascular System Interrelationships in Normal and in Failing Heart > 79-88

Although it is well-accepted that alterations in thyroid function occur in patients with heart failure, this was ascribed previously to “euthyroid-sick” syndrome rather than real hypothyroidism. This has been called into question by a series of reports that implicate a primary change in the myocardial response to thyroid hormone as being responsible, at least in part, for the changes in myocardial...

article

Bucindolol Prevents Atrial Flutter via the Beta-1 389 Arg/Gly Adrenergic Receptor Polymorphism

Ryan Aleong, Amrut Ambardekar, Gordan Davis, Michael R. Bristow

Journal of Cardiac Failure > 2015 > 21 > 8 Supplement > S49

article

Visual analysis of biological data-knowledge networks

Corinna Vehlow, David P Kao, Michael R Bristow, Lawrence E Hunter, more

BMC Bioinformatics > 2015 > 16 > 1 > 1-15

Background The interpretation of the results from genome-scale experiments is a challenging and important problem in contemporary biomedical research. Biological networks that integrate experimental results with existing knowledge from biomedical databases and published literature can provide a rich resource and powerful basis for hypothesizing about mechanistic explanations for observed gene-phenotype...

article

Is it Dead or Just Hibernating?

Christopher B. Fordyce, Matthew T. Roe, Tariq Ahmad, Peter Libby, more

Journal of the American College of Cardiology > 2015 > 65 > 15 > 1567-1582

Despite the global burden of cardiovascular disease, investment in cardiovascular drug development has stagnated over the past 2 decades, with relative underinvestment compared with other therapeutic areas. The reasons for this trend are multifactorial, but of primary concern is the high cost of conducting cardiovascular outcome trials in the current regulatory environment that demands a direct assessment...

article

New-onset Atrial Fibrillation Predicts Heart Failure Progression

Ryan G. Aleong, William H. Sauer, Gordon Davis, Michael R. Bristow

The American Journal of Medicine > 2014 > 127 > 10 > 963-971

Atrial fibrillation and heart failure with reduced left ventricular ejection fraction have interrelated pathophysiologies. New-onset atrial fibrillation in heart failure patients has been associated with increased mortality, but has not been definitively related to clinical heart failure progression.To test the hypothesis that new-onset atrial fibrillation is related to clinical heart failure progression,...

article

RNA Sequencing, Microarray Hybridization, and Quantitative PCR Produce Complementary, Concordant Results in Longitudinal Analysis of Myocardial Gene Expression in Dilated Cardiomyopathy Patients

David P. Kao, Wayne Minobe, Kenneth L. Jones, Ronald Zolty, more

Journal of Cardiac Failure > 2014 > 20 > 8 Supplement > S82

article

New Onset Atrial Fibrillation Is a Risk Factor for Ventricular Arrhythmias in Heart Failure

Ryan Aleong, William H. Sauer, Gordon Davis, Michael R. Bristow

Journal of Cardiac Failure > 2013 > 19 > 8 Supplement > S24

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INFONA - science communication portal

Search results for: Michael R. Bristow

The effect of cardiac resynchronization without a defibrillator on morbidity and mortality: an individual patient data meta‐analysis of COMPANION and CARE‐HF

Transcriptome analysis of human heart failure reveals dysregulated cell adhesion in dilated cardiomyopathy and activated immune pathways in ischemic heart failure

A genotype-directed comparative effectiveness trial of Bucindolol and metoprolol succinate for prevention of symptomatic atrial fibrillation/atrial flutter in patients with heart failure: Rationale and design of the GENETIC-AF trial

Contractile reserve and the response to cardiac resynchronization therapy

Improving Heart Failure Therapeutics Development in the United States

Histamine H2 Receptor Polymorphisms, Myocardial Transcripts, and Heart Failure (from the Multi-Ethnic Study of Atherosclerosis and Beta-Blocker Effect on Remodeling and Gene Expression Trial)

MicroRNAs in Heart Failure, Cardiac Transplantation, and Myocardial Recovery: Biomarkers with Therapeutic Potential

Outcomes of cardiac resynchronization therapy in patients with intermittent atrial fibrillation or atrial flutter in the COMPANION trial

Data and Safety Monitoring Board evaluation and management of a renal adverse event signal in TOPCAT

Genetic variation expressed in the brain may impact heart failure

Reply

Histamine H2 Receptor Antagonists, Left Ventricular Morphology, and Heart Failure Risk

Sex-related differences in age-associated downregulation of human ventricular myocardial β1-adrenergic receptors

Thyroid Hormone Receptor Signaling in Normal and Failing Heart

Bucindolol Prevents Atrial Flutter via the Beta-1 389 Arg/Gly Adrenergic Receptor Polymorphism

Visual analysis of biological data-knowledge networks

Is it Dead or Just Hibernating?

New-onset Atrial Fibrillation Predicts Heart Failure Progression

RNA Sequencing, Microarray Hybridization, and Quantitative PCR Produce Complementary, Concordant Results in Longitudinal Analysis of Myocardial Gene Expression in Dilated Cardiomyopathy Patients

New Onset Atrial Fibrillation Is a Risk Factor for Ventricular Arrhythmias in Heart Failure

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