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Serotonergic neurotransmission plays a key role in the pathophysiology and treatment of various neuropsychiatric diseases. The purpose of this study was to investigate changes in serotonergic neurotransmission after acute tryptophan depletion (ATD) using positron emission tomography (PET) with [11C]P943, a 5‐HT1B receptor radioligand previously shown to be sensitive to changes in 5‐HT. Five healthy...
The main objective of the current study was to determine the sensitivity of the positron emission tomography (PET) radioligand [11C]P943 to fenfluramine‐induced changes in endogenous 5‐HT in nonhuman primate brain. Fenfluramine‐induced changes in 5‐HT1B occupancy were compared to those obtained by self‐block with unlabeled P943. Two baboons and 1 rhesus monkey were given preblocking or displacing...
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