Search results for: Carina Stenfors

Items from 1 to 20 out of 25 results

article

Using gait analysis to assess weight bearing in rats with Freund׳s complete adjuvant-induced monoarthritis to improve predictivity: Interfering with the cyclooxygenase and nerve growth factor pathways

Kristina Ängeby Möller, Odd-Geir Berge, Anja Finn, Carina Stenfors, more

European Journal of Pharmacology > 2015 > 756 > Complete > 75-84

Lack of predictive power for drug effects has been a major criticism against animal pain models. It is therefore important to define the utility and limitations of different models. The aim of this study was to extend previous work on gait analysis as a tool to investigate pharmacological effects in monoarthritic rats, specifically to test the hypothesis that monoarthritis induced by Freund׳s complete...

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DSP4, a Selective Neurotoxin for the Locus Coeruleus Noradrenergic System. A Review of Its Mode of Action

Svante B. Ross, Carina Stenfors

Neurotoxicity Research > 2015 > 27 > 1 > 15-30

DSP4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride) is a selective neurotoxin for the locus coeruleus noradrenergic system in the rodent and bird brain. It readily passes the blood–brain barrier and cyclizes to a reactive aziridinium derivative that is accumulated into the noradrenergic nerve terminals via the noradrenaline transporter. DSP4 is also an irreversible inhibitor of this...

article

The selective 5-HT1A receptor antagonist NAD-299 increases acetylcholine release but not extracellular glutamate levels in the frontal cortex and hippocampus of awake rat

Jan Kehr, Xiao-Jing Hu, Takashi Yoshitake, Fu-Hua Wang, more

European Neuropsychopharmacology > 2010 > 20 > 7 > 487-500

The effects of the HT _1A receptor antagonist NAD-299 on extracellular acetylcholine (ACh) and glutamate (Glu) levels in the frontal cortex (FC) and ventral hippocampus (HPC) of the awake rats were investigated by the use of in vivo microdialysis. Systemic administration of NAD-299 (0.3; 1 and 3µmol/kg s.c.) caused a dose-dependent increase in ACh levels in FC and HPC (peak value of 209% and...

article

Effects of the 5-HT1B receptor antagonist NAS-181 on extracellular levels of acetylcholine, glutamate and GABA in the frontal cortex and ventral hippocampus of awake rats: A microdialysis study

Xiao Jing Hu, Fu-Hua Wang, Carina Stenfors, Sven Ove Ögren, more

European Neuropsychopharmacology > 2007 > 17 > 9 > 580-586

The purpose of this study was to investigate the effects of the 5-HT _1B receptor antagonist NAS-181 ((R)-(+)-2-(3-morpholinomethyl-2H-chromen-8-yl) oxymethyl-morpholine methanesulfonate) on cholinergic, glutamatergic and GABA-ergic neurotransmission in the rat brain in vivo. Extracellular levels of acetylcholine, glutamate and GABA were monitored by microdialysis in the frontal cortex (FC)...

article

In vitro characterization of AR-A000002, a novel 5-hydroxytryptamine1B autoreceptor antagonist

Charlotte Ahlgren, Anders Eriksson, Pernilla Tellefors, Svante B. Ross, more

European Journal of Pharmacology > 2004 > 499 > 1-2 > 67-75

The in vitro pharmacological properties of AR-A000002 ((R)-N-[5-methyl-8-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydro-2-naphthyl]-4-morpholinobenzamide), a novel 5-hydroxytryptamine (5-HT) _1B receptor antagonist, were studied. AR-A000002 bound with high affinity to guinea pig cortex and recombinant guinea pig 5-HT _1B receptors (K _i =0.24 and 0.47 nM) and with 10-fold lower affinity...

article

Modulation of neuronal glutamate transporter rEAAC1 mRNA expression in rat brain by amitriptyline

Josefine Andin, Carina Stenfors, Svante B. Ross, Jan Marcusson

Molecular Brain Research > 2004 > 126 > 1 > 74-77

Glutamate transporters regulate the glutamate concentration in the synaptic cleft within the CNS, a regulation required for normal brain function. In several neurological conditions, the amount of glutamate is altered. One reason for the changes in glutamate concentration might be impaired glutamate transporter function. In this study, an in situ hybridisation technique has been used to elucidate...

article

Pharmacology of a novel selective 5-hydroxytryptamine1B receptor antagonist, AR-A000002

Carina Stenfors, Teresa Hallerbck, Lars-Gunnar Larsson, Carin Wallsten, more

Naunyn-Schmiedeberg's Archives of Pharmacology > 2004 > 369 > 3 > 330-337

The terminal 5-HT1B autoreceptors have attracted great pharmacological interest since they are potential targets for compounds modifying serotonergic neurotransmission. In the present work the in vivo biochemical properties of AR-A000002 ((R)-N-[5-methyl-8-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydro-2-naphthyl]-4-morpholinobenzamide), a novel selective 5-HT1B receptor antagonist, are reported. The...

article

Effects of long-term administration of the 5-hydroxytryptamine1B receptor antagonist AR-A000002 to guinea pigs

Carina Stenfors, Charlotte Ahlgren, Hong Yu, Maria Wedn, more

Psychopharmacology > 2004 > 172 > 3 > 333-340

Rationale. Recently a new 5-hydroxytryptamine1B (5-HT1B)-receptor antagonist, AR-A000002, was described. It was shown that this compound dose dependently increased 5-HT metabolism and release in guinea pig brain following a single injection. Objectives. The present study investigated effects of 3weeks twice-daily treatment of guinea pigs with the 5-HT1B-receptor antagonist AR-A000002 on the serotonergic...

article

Changes in extracellular 5-HIAA concentrations as measured by in vivo microdialysis technique in relation to changes in 5-HT release

Carina Stenfors, Svante B. Ross

Psychopharmacology > 2004 > 172 > 2 > 119-128

Rationale. The cerebral microdialysis technique has been widely used to monitor the release of 5-hydroxytryptamine (5-HT). The extracellular concentration of 5-HT has generally been shown to change after pharmacological manipulation as expected. Extracellular levels of the metabolite, 5-hydroxyindoleaceticacid (5-HIAA) does not always change in the same direction as 5-HT and has therefore generally...

article

Evidence for involvement of 5-hydroxytryptamine ₁ _B autoreceptors in the enhancement of serotonin turnover in the mouse brain following repeated treatment with fluoxetine

Carina Stenfors, Svante B. Ross

Life Sciences > 2002 > 71 > 24 > 2867-2880

The effect of repeated treatment with the selective serotonin reuptake inhibitor fluoxetine on synthesis and turnover of 5-hydroxytryptamine (5-HT) was studied in the mouse brain in vivo. The concentration of 5-hydroxytryptophan (5-HTP), 5-hydroxyindoleacetic acid (5-HIAA) and 5-HT was measured in hypothalamus, hippocampus and frontal cortex after inhibition of the aromatic amino acid decarboxylase...

article

Failure to detect in vivo inverse agonism of the 5-HT1B receptor antagonist SB-224289 in 5-HT-depleted guinea-pigs

Carina Stenfors, Svante Ross

Naunyn-Schmiedeberg's Archives of Pharmacology > 2002 > 365 > 6 > 462-467

Abstract. The possibility that 5-HT1B receptors display constitutive activity in vivo, i.e. have a basal agonist-independent activity, was examined in guinea-pigs depleted of endogenous brain 5-HT by pre-treatment with reserpine. Under these conditions (5mg/kg s.c. reserpine 24h before the experiment), hypothalamic 5-HT concentration was reduced by more than 97%. In reserpine-treated animals, 5-HT...

article

NGF modulates CGRP synthesis in human B-lymphocytes: a possible anti-inflammatory action of NGF?

Luisa Bracci-Laudiero, Luigi Aloe, Pasquale Buanne, Anja Finn, more

Journal of Neuroimmunology > 2002 > 123 > 1-2 > 58-65

We investigated whether the sensory neuropeptide, calcitonin gene-related peptide (CGRP), could be synthesised by human lymphocytes. Our results indicate that in activated B-cells, there is a strong expression of CGRP gene transcripts, which is almost absent in resting cells.Since B-cells autocrinally produce NGF, the neutralisation of endogenous NGF by anti-NGF antibodies resulted in a marked reduction...

article

Hypothermia reduces the rate of dissociation of specific ligands from dopamine-D2 and 5-hydroxytryptamine1A receptors in the mouse brain in vivo

Carina Stenfors, Svante Ross

Naunyn-Schmiedeberg's Archives of Pharmacology > 2001 > 364 > 5 > 479-486

Abstract. Factors influencing the disappearance of radioactivity from mouse brain after injections of tracer doses of the very selective receptor antagonists [3H]raclopride and [3H]robalzotan (NAD-299) which bind with high affinity to dopamine-D2 and 5-hydroxytryptamine1A receptors, respectively, were studied. For both ligands the amount of radioactivity in cerebellum was taken as non-specific binding...

article

RT-PCR ELISA method for the analysis of neurotrophin mRNA expression in brain and peripheral tissues

Paola Tirassa, Luigi Manni, Carina Stenfors, Thomas Lundeberg, more

Journal of Biotechnology > 2000 > 84 > 3 > 259 - 272

The levels of nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF) in brain and periphery are susceptible to changes during development and as result of different physiopathological conditions, such as stress and aging and during the onset and progression of neurological and autoimmune diseases. Despite the sensitive methods for measurement of neurotrophin protein levels in different...

article

Altered levels of neuropeptides characterize the brain of lupus prone mice

Luisa Bracci-Laudiero, Luigi Aloe, Thomas Lundeberg, Elvar Theodorsson, more

Neuroscience Letters > 1999 > 275 > 1 > 57-60

It has been reported that more than 50% of lupus patients show various forms of neurological deficits including impaired cognitive functions and psychiatric disorders. Using an animal model of lupus we investigated the production of neuropeptides in the brain of NZB/W F1 female hybrid mice and its parental strain NZB and NZW. Our results indicate that the alteration in learning and memory described...

article

Sex differences in neuropeptide distribution in the rat brain - comparative potencies of various polypeptides on brain NPY binding and biological responses in the rat vas deferens

Olof Rugarn, Mats Hammar, Annette Theodorsson, Elvar Theodorsson, more

Peptides > 1999 > 20 > 1 > 81-86

We have investigated possible sex differences in the regional concentrations of neuropeptides in the rat brain. Immunoreactive neurotensin (NT), neurokinin A (NKA), galanin (GAL), calcitonin gene-related peptide (CGRP), substance P (SP) and neuropeptide Y (NPY) were measured by radioimmunoassay in frontal cortex, occipital cortex, hippocampus, striatum, hypothalamus and pituitary in male and female...

article

Changes in dietary fatty acids alter phospholipid fatty acid composition in selected regions of rat brain

Ina Marteinsdottir, David F. Horrobin, Carina Stenfors, Elvar Theodorsson, more

Progress in Neuropsychopharmacology & Biological Psychiatry > 1998 > 22 > 6 > 1007-1021

1. Eighty rats were randomized into four groups receiving one of the following diets: rat chow containing (1) 6% soybean oil, (2) 6% primrose oil, (3) 6% fish oil, (4) a combination of 4.5% primrose and 1.5% fish oil.2. Following two months of each regimen, the rats were sacrificed by microwave irradiation and the brain's fatty acid composition was analysed with gas chromatography for each of the...

article

Neuropeptide Y, neurokinin A and neurotensin in brain regions of fawn hooded depressed , wistar, and sprague dawley rats. Effects of electroconvulsive stimuli

Aleksander A. Mathé, Patricia A. Jimenez, Elvar Theodorsson, Carina Stenfors

Progress in Neuropsychopharmacology & Biological Psychiatry > 1998 > 22 > 3 > 529-546

1. Concentrations of neuropeptide Y (NPY)-, neurokinin A (NKA)- and neurotensin (NT)-like immunoreactivity (-LI) were measured in brain tissues of Fawn Hooded (FH) (a model of depression), Wistar (W) (control for depression) and Sprague Dawley (SD) rats (control for strain) with the aim to explore possible associations between neuropeptides and models of depression.2. In addition, peptides were determined...

article

Modification of lymphoid and brain nerve growth factor levels in systemic lupus erythematosus mice

Luisa Bracci-Laudiero, Thomas Lundeberg, Carina Stenfors, Elvar Theodorsson, more

Neuroscience Letters > 1996 > 204 > 1-2 > 13-16

In the present work we investigated the production of nerve growth factor (NGF) in the brain and peripheral tissues of female NZB/W F1 mice, a well characterized model of murine lupus. Our results indicate that while no significant difference in the NGF content was observed in the sera and tissues of NZB/W mice and its parental strains during the first months of life, the levels of circulating NGF...

article

Significant changes in neuropeptide concentrations in the brain of normotensive (WKY) and spontaneously hypertensive (SHR) rats following knee joint monoarthritis

Indre Bileviciute, Carina Stenfors, Elvar Theodorsson, Mats Beckman, more

Brain Research > 1995 > 704 > 1 > 71-78

Changes induced by chronic monoarthritis in the nervous system was studied by measuring concentrations of substance P (SP)-, neurokinin A (NKA)-, calcitonin gene-related peptide (CGRP)- and neuropeptide Y (NPY)-like immunoreactivities in the brain and in the knee joints of control and monoarthritic normotensive (WKY) and spontaneously hypertensive (SHR) rats on day 21 after the induction of monoarthritis...

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Search results for: Carina Stenfors

Using gait analysis to assess weight bearing in rats with Freund׳s complete adjuvant-induced monoarthritis to improve predictivity: Interfering with the cyclooxygenase and nerve growth factor pathways

DSP4, a Selective Neurotoxin for the Locus Coeruleus Noradrenergic System. A Review of Its Mode of Action

The selective 5-HT1A receptor antagonist NAD-299 increases acetylcholine release but not extracellular glutamate levels in the frontal cortex and hippocampus of awake rat

Effects of the 5-HT1B receptor antagonist NAS-181 on extracellular levels of acetylcholine, glutamate and GABA in the frontal cortex and ventral hippocampus of awake rats: A microdialysis study

In vitro characterization of AR-A000002, a novel 5-hydroxytryptamine1B autoreceptor antagonist

Modulation of neuronal glutamate transporter rEAAC1 mRNA expression in rat brain by amitriptyline

Pharmacology of a novel selective 5-hydroxytryptamine1B receptor antagonist, AR-A000002

Effects of long-term administration of the 5-hydroxytryptamine1B receptor antagonist AR-A000002 to guinea pigs

Changes in extracellular 5-HIAA concentrations as measured by in vivo microdialysis technique in relation to changes in 5-HT release

Evidence for involvement of 5-hydroxytryptamine ₁ _B autoreceptors in the enhancement of serotonin turnover in the mouse brain following repeated treatment with fluoxetine

Failure to detect in vivo inverse agonism of the 5-HT1B receptor antagonist SB-224289 in 5-HT-depleted guinea-pigs

NGF modulates CGRP synthesis in human B-lymphocytes: a possible anti-inflammatory action of NGF?

Hypothermia reduces the rate of dissociation of specific ligands from dopamine-D2 and 5-hydroxytryptamine1A receptors in the mouse brain in vivo

RT-PCR ELISA method for the analysis of neurotrophin mRNA expression in brain and peripheral tissues

Altered levels of neuropeptides characterize the brain of lupus prone mice

Sex differences in neuropeptide distribution in the rat brain - comparative potencies of various polypeptides on brain NPY binding and biological responses in the rat vas deferens

Changes in dietary fatty acids alter phospholipid fatty acid composition in selected regions of rat brain

Neuropeptide Y, neurokinin A and neurotensin in brain regions of fawn hooded depressed , wistar, and sprague dawley rats. Effects of electroconvulsive stimuli

Modification of lymphoid and brain nerve growth factor levels in systemic lupus erythematosus mice

Significant changes in neuropeptide concentrations in the brain of normotensive (WKY) and spontaneously hypertensive (SHR) rats following knee joint monoarthritis

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