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Astrocyte-elevated gene-1 was cloned as a human immunodeficiency virus-1-inducible and tumor necrosis factor-α-inducible transcript in primary human fetal astrocytes by a rapid subtraction hybridization approach. Astrocyte-elevated gene-1 down-regulates the expression of the glutamate transporter excitatory amino acid transporter 2, thus, it is implicated in glutamate-induced excitotoxic damage to...
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