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We investigated, whether the effects on paclitaxel, docetaxel or their combinations on T-cell lymphomas in Sprague–Dawley/Cub rats were mainly caused by their different efficiency or combination of different mechanism of action, or limited by metabolic inactivation by P450 enzymes or drug efflux caused by P-glycoprotein (P-gp). Docetaxel most effectively prolonged the survival of rats and the time...
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