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Previous experiments have demonstrated that [D-Ala 2 ,Glu 4 ]deltorphin (DELT) produces δ-receptor mediated antinociceptive effects when microinjected into the rat lateral ventricle and ventral medial medullary reticular formation (MRF), but not in the periaqueductal grey region (PAG). The present experiments were undertaken to further characterize the role of δ opioid agonists microinjected...
A new cyclic opioid peptide of sequence Tyr-D-Pen-Gly-Phe-Cys-Phe (HBP2) was examined in the mouse isolated vas deferens (MVD) bioassay. Studies with receptor-selective opioid antagonists showed the peptide to be highly selective for δ opioid receptors. HBP2 and the standard δ agonist DPDPE were simultaneously compared using the technique of partial irreversible receptor blockade; data were analyzed...
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