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The fruit of Dillenia indica L. is extensively used as a food additive. Betulinic acid (BA) is the most prominent secondary metabolite present in D. indica. This study screened the bioassay guided isolation of BA from D. indica and explored its tyrosinase inhibitory mechanism. Half maximal inhibitory concentration (IC50) of BA were calculated as 13.93µM and 25.66µM for diphenolase and monophenolase...
Betulinic acid (BA) is a potent bioactive compound and well known for its therapeutic activity. However, its efficacy is restricted due to low solubility as well as poor bioavailability. The aim of the study was to develop a BA loaded nanoemulsions for enhanced bioavailability and hepatoprotective activity. The optimized nanoemulsion (BA-NE1) was composed of olive oil, aqueous phase and Smix [surfactant...
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