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Inhibition of the proteasome, a multicatalytic proteinase complex, is an attractive approach to cancer therapy. Here we report that a selective inhibitor of the chymotrypsin-like activity of the proteasome, PSI (N-benzyloxycarbonyl-Ile-Glu(O-t-butyl)-Ala-leucinal) may inhibit growth of solid tumors not only through apoptosis induction, but also indirectly—through inhibition of angiogenesis. Two murine...
Lymphocyte-induced angiogenesis (LIA), a vascular response was observed when allogenic immunocompetent lymphocytes of C3H/w mice infected with Trichinella spiralis were inoculated intradermally into irradiated BALB/c. It was shown that intestinal phase of T. spiralis infection stimulated mainly CD5 T cells dependent angiogenesis. The enhancement of angiogenesis did not occur in the early and late...
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