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This study describes a non-conventional approach to the synthesis of 1-β-d-[2-deoxy-2-iodoarabinofuranosyl]-2-nitroimidazole (β-2-IAZA), a positional and configurational isomer of 1-α-d-[5-deoxy-5-iodoarabinofuranosyl]-2-nitroimidazole (IAZA). [ 123 I]IAZA, a radiopharmaceutical used clinically to image regional tissue hypoxia in a number of pathologies, is synthesized by coupling the appropriately...
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