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Antibiotics are highly successful against microbial infections. However, current challenges include rising antibiotic resistance rates and limited efficacy against intracellular pathogens. A novel form of a nanomaterial‐based antimicrobial agent is investigated for efficient treatment of an intracellular Salmonella enterica sv Typhimurium infection. A known antimicrobial polysaccharide, chitosan,...
Front Cover: Nanocomplexes of acid‐transforming chitosan (ATC) and DNA fragments are endocytosed to Salmonella Typhimurium‐infected macrophages. The mildly acidic environment in the phagolysosome converts ATC to an antimicrobial chitosan which is subsequently released from the nanocomplexes to effectively eradicates S. Typhimurium both in the phagolysosome and the cytoplasm via tackling a broad range...