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Purpose We explored the use of intraventricular 131I-Omburtamab targeting B7-H3 in patients with ETMR. Methods Patients were enrolled in an IRB approved, phase 1, 3 + 3 dose escalation trial. Patients with CNS disease expressing the antibody target antigen B7-H3 were eligible. We report on a cohort of three patients with ETMR who were enrolled on the study. Three symptomatic children (ages 14 months,...
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