Search results for: Christian Bronner

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ICBP90 Regulates MIF Expression, Glucocorticoid Sensitivity, and Apoptosis at the MIF Immune Susceptibility Locus

Jie Yao, Lin Leng, Weiling Fu, Jia Li, more

Arthritis & Rheumatology > 73 > 10 > 1931 - 1942

Objective Macrophage migration inhibitory factor (MIF) is an inflammatory and neurorendocrine mediator that counterregulates glucocorticoid immunosuppression. MIF polymorphisms, which comprise a variant promoter microsatellite (−794 CATT_5–8), are linked genetically to autoimmune disease severity and to glucocorticoid resistance. While invasive stimuli increase MIF expression, MIF also is up‐regulated...

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A Molecular Tool Targeting the Base‐Flipping Activity of Human UHRF1

Liliyana Zaayter, Mattia Mori, Tanveer Ahmad, Waseem Ashraf, more

Chemistry – A European Journal > 25 > 58 > 13363 - 13375

During DNA replication, ubiquitin‐like, containing PHD and RING fingers domains 1 (UHRF1) plays key roles in the inheritance of methylation patterns to daughter strands by recognizing through its SET and RING‐associated domain (SRA) the methylated CpGs and recruiting DNA methyltransferase 1 (DNMT1). Herein, our goal is to identify UHRF1 inhibitors targeting the 5′‐methylcytosine (5mC) binding pocket...

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Interaction of the epigenetic integrator UHRF1 with the MYST domain of TIP60 inside the cell

Waseem Ashraf, Christian Bronner, Liliyana Zaayter, Tanveer Ahmad, more

Journal of Experimental & Clinical Cancer Research > 2017 > 36 > 1 > 1-14

Background The nuclear epigenetic integrator UHRF1 is known to play a key role with DNMT1 in maintaining the DNA methylation patterns during cell division. Among UHRF1 partners, TIP60 takes part in epigenetic regulations through its acetyltransferase activity. Both proteins are involved in multiple cellular functions such as chromatin remodeling, DNA damage repair and regulation of stability and activity...

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Tandem virtual screening targeting the SRA domain of UHRF1 identifies a novel chemical tool modulating DNA methylation

Vassilios Myrianthopoulos, Pierre Francois Cartron, Zita Liutkevičiūtė, Saulius Klimašauskas, more

European Journal of Medicinal Chemistry > 2016 > 114 > C > 390-396

Ubiquitin-like protein UHRF1 that contains PHD and RING finger domain 1 is a key epigenetic protein enabling maintenance of the DNA methylation status through replication. A tandem virtual screening approach was implemented for identifying small molecules able to bind the 5-methylcytosine pocket of UHRF1 and inhibit its functionality. The NCI/DTP small molecules Repository was screened in silico by...

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Increasing role of UHRF1 in the reading and inheritance of the epigenetic code as well as in tumorogenesis

Christian Bronner, Mounira Krifa, Marc Mousli

Biochemical Pharmacology > 2013 > 86 > 12 > 1643-1649

Epigenetic mechanisms such as DNA methylation and histone posttranslational modifications, allow cells to maintain the phenotype throughout successive mitosis. UHRF1 plays a major role in the inheritance of some epigenetic marks from mother cells to daughter cells due to its particular structural domains. The originality of UHRF1 lies in the fact that it can read epigenetic marks and recruit the enzymes...

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Epigallocatechin-3-gallate up-regulates tumor suppressor gene expression via a reactive oxygen species-dependent down-regulation of UHRF1

Mayada Achour, Marc Mousli, Mahmoud Alhosin, Abdulkhaleg Ibrahim, more

Biochemical and Biophysical Research Communications > 2013 > 430 > 1 > 208-212

Ubiquitin-like containing PHD and Ring finger 1 (UHRF1) contributes to silencing of tumor suppressor genes by recruiting DNA methyltransferase 1 (DNMT1) to their hemi-methylated promoters. Conversely, demethylation of these promoters has been ascribed to the natural anti-cancer drug, epigallocatechin-3-gallate (EGCG). The aim of the present study was to investigate whether the UHRF1/DNMT1 pair is...

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Red wine polyphenols improve an established aging-related endothelial dysfunction in the mesenteric artery of middle-aged rats: Role of oxidative stress

Stéphanie Dal-Ros, Christian Bronner, Cyril Auger, Valérie B. Schini-Kerth

Biochemical and Biophysical Research Communications > 2012 > 419 > 2 > 381-387

Aging is associated with blunted endothelium-dependent relaxations and vascular oxidative stress. Our previous study has indicated that daily intake of red wine polyphenols (RWPs) by young rats retards aging-related endothelial dysfunction in middle-aged rats. The aim of the present study is to determine whether intake of RWPs also improves an established endothelial dysfunction in middle-aged rats...

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Anti‐proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1

Abdurazzag Abusnina, Thérèse Keravis, Issaka Yougbaré, Christian Bronner, more

Molecular Nutrition & Food Research > 55 > 11 > 1677 - 1689

Scope: Curcumin inhibits proliferation of many cancer cells. Cyclic nucleotide phosphodiesterases (PDEs), by hydrolyzing intracellular cyclic adenosine‐3′,5′‐monophosphate (cAMP) and/or cyclic guanosine‐3′,5′‐monophosphate (cGMP), play a pivotal role in signalling pathways involved in cell proliferation. Therefore, this study investigated PDE1–5 participations in the anti‐proliferative properties...

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Chronic intake of red wine polyphenols by young rats prevents aging-induced endothelial dysfunction and decline in physical performance: Role of NADPH oxidase

Stéphanie Dal-Ros, Joffrey Zoll, Anne-Laure Lang, Cyril Auger, more

Biochemical and Biophysical Research Communications > 2011 > 404 > 2 > 743-749

Aging is associated with oxidative stress-mediated endothelial dysfunction and decline in physical performance, which promote cardiovascular diseases. This study examined whether chronic intake of red wine polyphenols (RWPs), a rich source of natural antioxidants, prevents aging-related impairment of vascular function and physical exercise capacity. Vascular reactivity from 12, 20 and 40week-old rats...

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Selective proapoptotic activity of polyphenols from red wine on teratocarcinoma cell, a model of cancer stem-like cell

Tanveer Sharif, Cyril Auger, Christian Bronner, Mahmoud Alhosin, more

Investigational New Drugs > 2011 > 29 > 2 > 239-247

Summary Cancer stem cells are expected to be responsible for tumor initiation and metastasis. These cells are therefore potential targets for innovative anticancer therapies. However, the absence of bona fide cancer stem cell lines is a real problem for the development of such approaches. Since teratocarcinoma cells are totipotent stem cells with a high degree of malignancy, we used them as a model...

article

Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis

Abdurazzag Abusnina, Mahmoud Alhosin, Thérèse Keravis, Christian D. Muller, more

Cellular Signalling > 2011 > 23 > 1 > 152-160

Thymoquinone (TQ), the active principle of Nigella sativa black seeds, has anti-proliferative properties on numerous cancer cell types. Others and we have previously reported that TQ acts as agent that triggers cell cycle arrest and apoptosis through either a p53- or p73-dependent pathway. However, the immediate targets recruited upon TQ-induced cytotoxicity have not yet been clearly identified. We...

article

Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1

Mahmoud Alhosin, Abdurazzag Abusnina, Mayada Achour, Tanveer Sharif, more

Biochemical Pharmacology > 2010 > 79 > 9 > 1251-1260

The salvage anti-tumoral pathway which implicates the p53-related p73 gene is not yet fully characterized. We therefore attempted to identify the up- and down-stream events involved in the activation of the p73-dependent pro-apoptotic pathway, by focusing on the anti-apoptotic and epigenetic integrator UHRF1 which is essential for cell cycle progression. For this purpose, we analyzed the effects of...

article

Losartan Prevents Portal Hypertension-Induced, Redox-Mediated Endothelial Dysfunction in the Mesenteric Artery in Rats

Stéphanie Dal–Ros, Monique Oswald–Mammosser, Tatiana Pestrikova, Christa Schott, more

Gastroenterology > 2010 > 138 > 4 > 1574-1584

Advanced stages of portal hypertension are characterized by generalized vasodilatation and a hyperdynamic syndrome that leads to complications such as hepatopulmonary syndrome. We assessed the endothelial function—particularly the formation of nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF)—in rats following common bile duct ligation (CBDL) to determine the underlying mechanisms...

article

Red wine polyphenols cause growth inhibition and apoptosis in acute lymphoblastic leukaemia cells by inducing a redox-sensitive up-regulation of p73 and down-regulation of UHRF1

Tanveer Sharif, Cyril Auger, Mahmoud Alhosin, Claudine Ebel, more

European Journal of Cancer > 2010 > 46 > 5 > 983-994

Several epidemiological studies suggest that a diet rich in fruits and vegetables, which contain high levels of polyphenols, is associated with a reduced risk of cancer. The aim of the present study was to determine whether a red wine polyphenolic extract (RWPs, a rich source of polyphenols; 2.9g/L) affects the proliferation of human lymphoblastic leukaemia cells (Jurkat cells) and, if so, to determine...

article

UHRF1 recruits the histone acetyltransferase Tip60 and controls its expression and activity

Mayada Achour, Guy Fuhrmann, Mahmoud Alhosin, Philippe Rondé, more

Biochemical and Biophysical Research Communications > 2009 > 390 > 3 > 523-528

Tat-interactive protein, 60kDa (Tip60) is a histone acetyltransferase with specificity toward lysine 5 of histone H2A (H2AK5) and plays multiple roles in chromatin remodeling processes. Co-immunoprecipitation experiments performed on Jurkat cells, showed that Tip60 is present in the same macro-molecular complex as UHRF1 (Ubiquitin-like containing PHD and RING domain 1), DNMT1 (DNA methyltransferase...

article

ICBP90 mediates the ERK1/2 signaling to regulate the proliferation of Jurkat T cells

Zhiyuan Fang, Feiyue Xing, Christian Bronner, Zhenping Teng, more

Cellular Immunology > 2009 > 257 > 1-2 > 80-87

ERK1/2 activation leads to the release of E2F that could bind to the E2F binding sites in the inverted CCAAT box binding protein (ICBP90) gene promoter. Therefore, in the present study the relationship between ERK1/2 signaling and ICBP90 in the regulation of Jurkat T cell proliferation was explored. Jurkat T cells were treated with different concentrations of various signal pathway inhibitors. The...

article

The UHRF family: Oncogenes that are drugable targets for cancer therapy in the near future?

Christian Bronner, Mayada Achour, Yoshimi Arima, Thierry Chataigneau, more

Pharmacology and Therapeutics > 2007 > 115 > 3 > 419-434

In this paper, we review the current literature about the UHRF family that in particular includes the UHRF1 and UHRF2 genes. Its members play a fundamental role in cell proliferation through different structural domains. These domains include a ubiquitin-like domain (NIRF_N), a plant homeodomain (PHD) domain, a SRA domain and a RING domain. The SRA domain has only been observed in this family probably...

article

Cell cycle and/or proliferation markers: what is the best method to discriminate cervical high-grade lesions?

Marianne Lorenzato, Stephanie Caudroy, Christian Bronner, Ghislaine Evrard, more

Human Pathology > 2005 > 36 > 10 > 1101-1107

The aim of this study on a series of biopsies diagnosed as normal, metaplastic, low-grade squamous intraepithelial lesions (LSILs), and high-grade squamous intraepithelial lesions (HSILs) was dual: to determine the chronology of cell cycle and proliferation abnormalities after human papillomavirus infection during the development of squamous intraepithelial lesions and to determine the best diagnostic...

article

TCR pathway involves ICBP90 gene down-regulation via E2F binding sites

Abdul-Qader Abbady, Christian Bronner, Kawtar Bathami, Christian D. Muller, more

Biochemical Pharmacology > 2005 > 70 > 4 > 570-579

Antigen-induced cell death is essential for function, growth and differentiation of T-lymphocytes through legation of the T cell receptor. Since TCR-induced cell death occurs at late G1 checkpoint of the cell cycle and considering that ICBP90 is critical for G1/S transition, we studied the ICBP90 regulation through the TCR pathway in Jurkat cells. ICBP90 expression was strongly decreased after TCR...

article

1,25-Dihydroxyvitamin D3 induces splenocyte apoptosis and enhances BALB/c mice sensitivity to toxoplasmosis

Rohan Rajapakse, Marc Mousli, Alexander W. Pfaff, Béatrice Uring-Lambert, more

Journal of Steroid Biochemistry and Molecular Biology > 2005 > 96 > 2 > 179-185

The hormonal form of Vitamin D, 1,25-dihydroxyvitamin D3, is well known for its immunosuppressive, anti-proliferative and pro-apoptotic activities. In the present work, we studied the effect of 1,25-dihydroxyvitamin D3 on Toxoplasma gondii-infected mice. We observed that 1,25-dihydroxyvitamin D3 reduces the survival rate of infected mice by up to 37% at day 10 post-infection compared to untreated...

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Search results for: Christian Bronner

ICBP90 Regulates MIF Expression, Glucocorticoid Sensitivity, and Apoptosis at the MIF Immune Susceptibility Locus

A Molecular Tool Targeting the Base‐Flipping Activity of Human UHRF1

Interaction of the epigenetic integrator UHRF1 with the MYST domain of TIP60 inside the cell

Tandem virtual screening targeting the SRA domain of UHRF1 identifies a novel chemical tool modulating DNA methylation

Increasing role of UHRF1 in the reading and inheritance of the epigenetic code as well as in tumorogenesis

Epigallocatechin-3-gallate up-regulates tumor suppressor gene expression via a reactive oxygen species-dependent down-regulation of UHRF1

Red wine polyphenols improve an established aging-related endothelial dysfunction in the mesenteric artery of middle-aged rats: Role of oxidative stress

Anti‐proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1

Chronic intake of red wine polyphenols by young rats prevents aging-induced endothelial dysfunction and decline in physical performance: Role of NADPH oxidase

Selective proapoptotic activity of polyphenols from red wine on teratocarcinoma cell, a model of cancer stem-like cell

Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis

Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1

Losartan Prevents Portal Hypertension-Induced, Redox-Mediated Endothelial Dysfunction in the Mesenteric Artery in Rats

Red wine polyphenols cause growth inhibition and apoptosis in acute lymphoblastic leukaemia cells by inducing a redox-sensitive up-regulation of p73 and down-regulation of UHRF1

UHRF1 recruits the histone acetyltransferase Tip60 and controls its expression and activity

ICBP90 mediates the ERK1/2 signaling to regulate the proliferation of Jurkat T cells

The UHRF family: Oncogenes that are drugable targets for cancer therapy in the near future?

Cell cycle and/or proliferation markers: what is the best method to discriminate cervical high-grade lesions?

TCR pathway involves ICBP90 gene down-regulation via E2F binding sites

1,25-Dihydroxyvitamin D3 induces splenocyte apoptosis and enhances BALB/c mice sensitivity to toxoplasmosis

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