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The role of a nonsynonymous A118G polymorphism of the human μ-opioid receptor gene (OPRM1) for alcohol reward and therapeutic efficacy of naltrexone remains controversial. A functionally equivalent OPRM1 C77G polymorphism in rhesus macaques allows this to be addressed under controlled experimental conditions.Twenty-one rhesus macaques (13 female rhesus macaques, 8 male rhesus macaques) were genotyped...
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