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It is crucial to transport foreign substance into living cells efficiently and minimize adverse side-effects. Using ultrasound microbubble, it is possible to enhance the cellular uptake and transfer the extracellular molecules into cells, this process is called sonoporation. However, the spatial location of microbubbles appears to be a stochastic process, which makes the targeted sonoporation at specific...
Recent studies have proven that ultrasound as a non-invasive method enable to delivery energy to deep brain for both excitation and reversible suppression of neuronal activity in cell, animal, human experiments (Scientific Reports 6:24170, 2016; Neuron 66(5):681-694; Nature Neuroscience 17(2):322-9, 2014). Due to bulk ultrasound transducer, it is difficult to compatible the ultrasound stimulation...
Purpose: Hemodynamic changes in vascular stenosis could affect blood flow component of flow distribution which changed the nature of vascular smooth muscle cells. Observation and analysis of blood flow in the heart disease have important clinical significance of treatments of arterial stenosis. Method: The ultrasonic particle image velocimetry (Echo PIV) technique is appropriate for measuring blood...
A novel imaging processing method using gray level co-occurrence matrix (GLCM) to evaluate microbubble concentration in ultrasonic particle image velocimetry (echo PIV) technique is presented in this paper. The image processing method is used to study the optimum microbubble concentration in Echo PIV imaging of a two dimensional blood flow field. It is found that for the GLCM correlation values for...
Purpose: To develop optimal microbubble contrast agents for high frequency ultrasound imaging systems when examining small animals. Materials and Methods: We prepared microbubbles by encapsulate (Perfluoropropane) C3F8 into phospholipids shell, and the size distribution of the microbubbles was measured by PSS 780A particle sizing systems. A major peak was observed in the size distribution of the microbubbles...
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