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Objective
Laryngopharyngeal reflux disease (LPRD) is one of potential factors in recalcitrant chronic rhinosinusitis with or without polyps. An increase in junctional permeability in the nasal mucosa in LPRD may be due to disrupted protein bridge formation with cell‐to‐cell adhesion molecules such as E‐cadherin. Despite the relationship between nasal mucosal inflammation and LPRD, the clear mechanism...
Objectives/Hypothesis
Mucus hypersecretion is a hallmarks of chronic rhinosinusitis. The expression of MUC5AC, a major respiratory mucin gene, is increased in chronic rhinosinusitis. The mechanisms inducing mucus hypersecretion have not been fully evaluated in chronic rhinosinusitis. Human Ca2+‐activated Cl‐ channel 1 (hCLCA1) is implicated in the regulation of mucus production, airway fluid, and...
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