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Background To protect neurological tissues, underdosing occurs in most cases of T4 nasopharyngeal carcinoma (NPC) with intracranial extension. In this study, we aimed to evaluate the effect of dosimetric inadequacy on local control and late neurological toxicities for patients treated with intensity-modulated radiotherapy (IMRT) plus chemotherapy. Methods We prospectively enrolled patients who had...
To investigate the rate and risk factors for developing hypothyroidism (HT) in nasopharyngeal carcinoma (NPC) patients treated with intensity-modulated radiotherapy (IMRT).A total of 135 consecutive patients treated with IMRT for NPC were prospectively evaluated during a median follow up of 34.1months. Serum thyroid function assessments before and after IMRT were periodically monitored. To identify...
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