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Les etudes menees sur des xenogreffes de mesotheliome malin ont montre l'existence d'une synergie entre l'interferon-alfa associe au cisplatine ou a la mitomycine. L'association cisplatine-mitomycine est le traitement recommande depuis l'etude de Chahinian (JCO, 1993), aussi pouvait-on attendre une augmentation de l'activite de ce regime par l'interferon alfa.De juillet 1994 a novembre 1995, nous...
L'objectif de cette etude etait de determiner l'efficacite et la toxicite du docetaxel en premiere ligne de chimiotherapie pour des patients presentant des carcinomes epidermoides de la tete et du cou localement evolues non operables, ou metastiques. Le Taxotere etait perfuse en 1 heure, toutes les 3 semaines, a la dose de 100 mg/m 2 .Les patients presentant uniquement une recidive locale...
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