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Recently, we showed that the 20(S)-ginsenoside Rg 3 (Rg 3 ), an active ingredient of Panax ginseng, inhibits rat brain Na V 1.2 channel peak currents (I Na ). Batrachotoxin (BTX) is a steroidal alkaloid neurotoxin and activates Na V channels through interacting with transmembrane domain-I-segment 6 (IS6) of channels. Recent report shows that ginsenoside inhibits...
We previously demonstrated that ginsenoside Rg 3 (Rg 3 ), one of the active ingredients in Panax ginseng, attenuates NMDA receptor-mediated currents and NMDA-induced neurotoxicity (Kim, S., Kim, T., Ahn, K., Park, W.K., Nah, S.Y., Rhim, H., 2004. Ginsenoside Rg 3 antagonizes NMDA receptors through a glycine modulatory site in rat cultured hippocampal neurons. Biochem. Biophys...
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