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Shear stress, autophagy and LOX-1 are important players in atherogenesis. Direct impact of shear stress on autophagy development in endothelial cells and role of LOX-1 therein are undelineated.A parallel-plate flow chamber was used to vary shear stress (3 to 30dyn/cm2), and determine autophagy in endothelial cells. We observed that low shear stress (3dyn/cm2) enhanced autophagy (expression of LC3-II)...
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