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ABSTRACTAcute promyelocytic leukemia (APL) is characterized by the expansion of malignant myeloid cells blocked at the promyelocytic stage of differentiation and is associated with reciprocal chromosomal translocations always involving the retinoic acid receptor α (RARα) gene on chromosome 17. As a consequence of the translocation, RARα variably fuses to the PML, PLZF, NPM, NuMA, and Stat5b genes...
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