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This chapter discusses the silicon cellsilicon cell silicon cell silicon cell paradigmparadigm , i.e. the existing systems biologysystems biology activity of making experiment-based computer replicacomputer replica of parts of biological systems. Now that such mathematical modelsmathematical models are accessible to in silico experimentation through the World-Wide Webworld-wide web , a new...
In this paper we propose a model-order reduction method for chemical reaction networks governed by general enzyme kinetics, including the mass-action and Michaelis-Menten kinetics. The model-order reduction method is based on the Kron reduction of the weighted Laplacian matrix which describes the graph structure of complexes in the chemical reaction network. We apply our method to a yeast glycolysis...
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