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(+)-[ 76 Br]A-69024 is a specific and enantioselective dopamine D1 receptor radioligand. The Bmax of (+)-[ 76 Br]A-69024 measured in vitro on rat striatum membranes was 320 +/- 25 fmoles/mg protein with an apparent dissociation constant of Kd = 0.6 +/- 0.1 nM. The inactive enantiomer, (-)-[ 76 Br]A-69024, displayed no affinity in the same assay. In vivo, the...
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