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As an evolutionarily conserved serine/threonine kinase of the phosphoinositide 3-kinase (PI3K) related kinase family, the mechanistic/mammalian target of rapamycin (mTOR) plays vital roles in the PI3K/AKT/mTOR pathway, participating in different cellular processes including cell survival, metabolism and proliferation. Aberrant activity of this signaling pathway may lead to oncogenesis. Over the last...
Polyketides are important compounds with a staggering range of biological and medicinal activities. Previous studies have demonstrated that the addition of fatty acids can increase polyketides production. However, a detailed metabolic explanation of this phenomenon has not been established. The aim of this study was to explain the positive effect of exogenous fatty acids on polyketides production...
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