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Contrast agent-enhanced ultrasound can facilitate personalized therapeutic strategies by providing the technology to measure local blood flow rate, to selectively image receptors on the vascular endothelium, and to enhance localized drug delivery. Ultrasound contrast agents are micron-diameter encapsulated bubbles that circulate within the vascular compartment and can be selectively imaged with ultrasound...
The development of targeted ultrasound contrast agents has brought ultrasound imaging into the arena of molecular imaging. In particular, targeted microbubbles are now utilized to detect angiogenesis in the early phase of tumor development. The detection of bound agents in a low mechanical index imaging scheme is desirable for clinical application. Here, we present a novel quantitative ultrasound...
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