Search results for: Flavia Trettel

Items from 1 to 15 out of 15 results

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Fractalkine in the nervous system: neuroprotective or neurotoxic molecule?

Clotilde Lauro, Myriam Catalano, Flavia Trettel, Cristina Limatola

Annals of the New York Academy of Sciences > 1351 > 1 > 141 - 148

Fractalkine (CX3CL1) is an intriguing chemokine that plays a central role in the nervous system. The expression of CX3CL1 on neurons and of its receptor CX3CR1 on microglia facilitates a privileged interaction, playing important roles in regulating the function and maturation of these cells. CX3CL1 is reported to have neuroprotective and anti‐inflammatory activities in several experimental systems...

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Adenosine A2A receptor induces protein kinase A‐dependent functional modulation of human α3β4 nicotinic receptor

Silvia Di Angelantonio, Alessio Piccioni, Claudia Moriconi, Flavia Trettel, more

The Journal of Physiology > 589 > 11 > 2755 - 2766

Non‐technical summary In many brain regions, adenosine regulates the function of the nicotinic acetylcholine receptor–channel, which allows the movement of ions across neuronal membrane if nicotine or acetylcholine is present. In this work we use a very controlled experimental system to study the details of adenosine action. We show that adenosine enhances the function of the receptor–channel when...

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Mutant human β4 subunit identified in amyotrophic lateral sclerosis patients impairs nicotinic receptor function

Claudia Moriconi, Silvia Angelantonio, Alessio Piccioni, Flavia Trettel, more

Pflügers Archiv - European Journal of Physiology > 2011 > 461 > 2 > 225-233

Recently identified mutations in the genes encoding the neuronal nicotinic ACh receptor (nAChR) subunits in patients affected by sporadic amyotrophic lateral sclerosis (sALS) may represent a factor which enhances disease susceptibility, in particular in association with ambient causes such as cigarette smoking. In this work, we characterize the functional properties of nAChRs containing the β4R349C...

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Chemokines and chemokine receptors in the nervous system Rome, 24/25 October, 2009, 2nd workshop

Flavia Trettel, Silvia Di Angelantonio, Cristina Limatola, Richard M. Ransohoff

Journal of Neuroimmunology > 2010 > 224 > 1-2 > 1-7

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LTP impairment by fractalkine/CX3CL1 in mouse hippocampus is mediated through the activity of adenosine receptor type 3 (A3R)

Laura Maggi, Flavia Trettel, Maria Scianni, Cristina Bertollini, more

Journal of Neuroimmunology > 2009 > 215 > 1-2 > 36-42

We have examined how the chemokine fractalkine/CX ₃ CL1 influences long-term potentiation (LTP) in CA1 mouse hippocampal slices. Field potentials (fEPSPs) were recorded upon electrical stimulation of Schaffer collaterals. It was found that application of CX ₃ CL1 inhibits LTP when present during the critical induction period. LTP impairment (i) failed to occur in CX ₃ CR1 deficient...

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Rome, 27/28 October, 2007

Flavia Trettel, Silvia Di Angelantonio, Cristina Limatola, Richard M. Ransohoff

Journal of Neuroimmunology > 2008 > 198 > 1-2 > 1-8

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Chemokine CXCL8 modulates GluR1 phosphorylation

Myriam Catalano, Flavia Trettel, Raffaela Cipriani, Clotilde Lauro, more

Journal of Neuroimmunology > 2008 > 198 > 1-2 > 75-81

The chemokine interleukin 8/CXCL8 induces the phosphorylation of the GluR1 subunit of the AMPA-type glutamate receptor in neurons and transfected HEK cells, on both serine 845 (S845) and 831 (S831) residues. We previously described that CXCL8 receptor CXCR2 and GluR1 co-precipitate and that GluR1/CXCR2 co-expression both in HEK cells and neurons impairs CXCL8-induced cell migration. Here we show that...

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Cysteine residues are critical for chemokine receptor CXCR2 functional properties

Cristina Limatola, Sabrina Di Bartolomeo, Myriam Catalano, Flavia Trettel, more

Experimental Cell Research > 2005 > 307 > 1 > 65-75

We examined the role of cysteine (Cys) residues present in chemokine receptor CXCR2 for proper surface expression, dimerization, signaling, and chemotaxis. To address this issue, serine or leucine residues were substituted for Cys, generating nine CXCR2 mutants transiently expressed in HEK cells. Single substitution of Cys residues present in the three extracellular loops (C119L, C196L, C286S) or...

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Signalling pathways involved in the chemotactic activity of CXCL12 in cultured rat cerebellar neurons and CHP100 neuroepithelioma cells

Francesca Floridi, Flavia Trettel, Sabrina Di Bartolomeo, Maria Teresa Ciotti, more

Journal of Neuroimmunology > 2003 > 135 > 1-2 > 38-46

We compared the signal transduction pathways activated by stromal cell-derived factor-1 (CXCL12) chemokine in two different cell systems: primary cultures of rat cerebellar granule neurons (CGN) and human neuroepithelioma CHP100 cells. Both cell types express functional CXC chemokine receptor 4 (CXCR4), which is coupled both to extracellular signal-regulated kinase (ERK) and Akt phosphorylation pathways...

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Expression of AMPA-type glutamate receptors in HEK cells and cerebellar granule neurons impairs CXCL2-mediated chemotaxis

Cristina Limatola, Sabrina Di Bartolomeo, Flavia Trettel, Clotilde Lauro, more

Journal of Neuroimmunology > 2003 > 134 > 1-2 > 61-71

We find that cerebellar granule neurons (CGN) obtained from newborn rats (p3) migrate in response to both CXC chemokine ligand-2 (CXCL2) and -12 (CXCL12), while CGN from p7 rats are unresponsive to CXCL2. The expression of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-type glutamate receptor 1 (GluR1) greatly impairs the chemotaxis induced by CXCL2 in CXCR2-expressing HEK cells. By immunoprecipitation,...

article

Complete Loss of P/Q Calcium Channel Activity Caused by a CACNA1A Missense Mutation Carried by Patients with Episodic Ataxia Type 2

Serena Guida, Flavia Trettel, Stefano Pagnutti, Elide Mantuano, more

The American Journal of Human Genetics > 2001 > 68 > 3 > 759-764

Familial hemiplegic migraine, episodic ataxia type 2 (EA2), and spinocerebellar ataxia type 6 are allelic disorders of the CACNA1A gene (coding for the α _1A subunit of P/Q calcium channels), usually associated with different types of mutations (missense, protein truncating, and expansion, respectively). However, the finding of expansion and missense mutations in patients with EA2 has blurred...

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A fine physical map of the CACNA1A gene region on 19p13.1-p13.2 chromosome

Flavia Trettel, Elide Mantuano, Valentina Calabresi, Liana Veneziano, more

Gene > 2000 > 241 > 1 > 45-50

The P/Q-type Ca ² ⁺ channel α ₁ _A subunit gene (CACNA1A) was cloned on the short arm of chromosome 19 between the markers D19S221 and D19S179 and found to be responsible for Episodic Ataxia type 2, Familial Hemiplegic Migraine and Spinocerebellar Ataxia type 6. This region was physically mapped by 11 cosmid contigs spanning about 1.4Mb, corresponding to less than 70% of the...

article

Mutant Huntingtin Forms in Vivo Complexes with Distinct Context-Dependent Conformations of the Polyglutamine Segment

Francesca Persichetti, Flavia Trettel, C.Chris Huang, Cornel Fraefel, more

Neurobiology of Disease > 1999 > 6 > 5 > 364-375

Huntington's disease (HD) is caused by an expanded glutamine tract, which confers a novel aggregation-promoting property on the 350-kDa huntingtin protein. Using specific antibodies, we have probed the structure of the polyglutamine segment in mutant huntingtin complexes formed in cell culture from either truncated or full-length protein. Complexes formed by a mutant amino terminal fragment most frequently...

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Two Exon-Skipping Mutations as the Molecular Basis of Succinic Semialdehyde Dehydrogenase Deficiency (4-Hydroxybutyric Aciduria)

Ken L. Chambliss, Debra D. Hinson, Flavia Trettel, Patrizia Malaspina, more

The American Journal of Human Genetics > 1998 > 63 > 2 > 399-408

Succinic semialdehyde dehydrogenase (SSADH) deficiency, a rare metabolic disorder of 4-aminobutyric acid degradation, has been identified in ∼150 patients. Affected individuals accumulate large quantities of 4-hydroxybutyric acid, a compound with a wide range of neuropharmacological activities, in physiological fluids. As a first step in beginning an investigation of the molecular genetics of SSADH...

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Construction of a YAC Contig Covering Human Chromosome 6p22

Patrizia Malaspina, Antonella Roetto, Flavia Trettel, Carla Jodice, more

Genomics > 1996 > 36 > 3 > 399-407

A contig covering human chromosome 6p22 that consists of 134 YAC clones aligned based on the presence/absence of 52 DNA markers is presented. This contig overlaps with the 6p23 contig at its telomeric end and with the 6p21.3 contig at its centromeric end. The order of loci within the contig resolves the relative positions of several genetically mapped markers. Among the additional markers used here,...

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