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Experimental evidence that a biomolecule corona self‐assembles around clinically used nanoparticles in humans while in their blood circulation is presented by Kostas Kostarelos and co‐workers in article number 1803335. The successful recovery and purification of corona‐coated lipid bilayer vesicles (liposomes) from the blood circulation of ovarian carcinoma patients allows the proteomic analysis of...
The self‐assembled layered adsorption of proteins onto nanoparticle (NP) surfaces, once in contact with biological fluids, is termed the “protein corona” and it is gradually seen as a determinant factor for the overall biological behavior of NPs. Here, the previously unreported in vivo protein corona formed in human systemic circulation is described. The human‐derived protein corona formed onto PEGylated...
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