Search results for: John W. Scott

Items from 1 to 20 out of 58 results

article

Understanding the impacts of rural hospital closures: A scoping review

Cody Lendon Mullens, J. Andres Hernandez, Jeevan Murthy, Steph Hendren, more

The Journal of Rural Health > 40 > 2 > 227 - 237

Purpose Rural hospitals are closing at unprecedented rates, with hundreds more at risk of closure in the coming 2 years. Multiple federal policies are being developed and implemented without a salient understanding of the emerging literature evaluating rural hospital closures and its impacts. We conducted a scoping review to understand the impacts of rural hospital closure to inform ongoing policy...

article

High‐risk surgery among Medicare beneficiaries living in health professional shortage areas

Cody Lendon Mullens, Alisha Lussiez, John W. Scott, Nicholas Kunnath, more

The Journal of Rural Health > 39 > 4 > 824 - 832

Purpose Americans who reside in health professional shortage areas currently have less than half of the needed physician workforce. While the shortage designation has been associated with poor outcomes for chronic medical conditions, far less is known about outcomes after high‐risk surgical procedures. Methods We performed a retrospective review of Medicare beneficiaries living in health professional...

article

Patient adverse financial outcomes before and after COVID‐19 infection

Nora V. Becker, Erin F. Carlton, Theodore J. Iwashyna, John W. Scott, more

Journal of Hospital Medicine > 18 > 5 > 424 - 428

Adverse financial outcomes after COVID‐19 infection and hospitalization have not been assessed with appropriate comparators to account for other financial disruptions of 2020–2021. Using credit report data from 132,109 commercially insured COVID‐19 survivors, we compared the rates of adverse financial outcomes for two cohorts of individuals with credit outcomes measured before and after COVID‐19 infection,...

article

Differences Between Emergency Department and Urgent Care Users for Low‐acuity Health Needs: A Public Opinion Analysis

Kirstin W. Scott, Mary G. Findling, Haiden A. Huskamp, John W. Scott, more

Academic Emergency Medicine > 28 > 2 > 240 - 243

article

Functional analysis of an R311C variant of Ca²⁺‐calmodulin‐dependent protein kinase kinase‐2 (CaMKK2) found as a de novo mutation in a patient with bipolar disorder

Naomi XY Ling, Christopher G. Langendorf, Ashfaqul Hoque, Sandra Galic, more

Bipolar Disorders > 22 > 8 > 841 - 848

Objectives Loss‐of‐function mutations in the gene encoding the calcium‐calmodulin (Ca²⁺‐CaM)‐dependent protein kinase kinase‐2 (CaMKK2) enzyme are linked to bipolar disorder. Recently, a de novo arginine to cysteine (R311C) mutation in CaMKK2 was identified from a whole exome sequencing study of bipolar patients and their unaffected parents. The aim of the present study was to determine the functional...

article

Ty-6, a major begomovirus resistance gene on chromosome 10, is effective against Tomato yellow leaf curl virus and Tomato mottle virus

Upinder Gill, John W. Scott, Reza Shekasteband, Eben Ogundiwin, more

Theoretical and Applied Genetics > 2019 > 132 > 5 > 1543-1554

Key message Ty-6 is a major resistance gene on chromosome 10 of tomato that provides resistance against monopartite and bipartite begomoviruses and complements resistance conferred by the known Ty-3 and ty-5 genes. Abstract Resistance to monopartite and bipartite begomoviruses is an important breeding objective for cultivated tomato. Several begomovirus resistance genes have been introgressed from...

article

The impact of individual physicians on outcomes after trauma: is it the system or the surgeon?

N. Rhea Udyavar, Ali Salim, Joaquim M. Havens, Zara Cooper, more

Journal of Surgical Research > 2018 > 229 > C > 51-57

Benchmarking of mortality outcomes across the country has revealed major differences in survival based on the trauma center at which a patient receives care. The role of the individual surgeon in determining trauma outcomes is unknown. Most believe that differences in outcomes are primarily driven by system- and process-based variations. Our objective was to determine if variation in individual surgeon...

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Global surgical, obstetric, and anesthetic task shifting: A systematic literature review

Frederik Federspiel, Swagoto Mukhopadhyay, Penelope J. Milsom, John W. Scott, more

Surgery > 2018 > 164 > 3 > 553-558

Five billion people lack access to safe, affordable, and timely surgical care; this is in part driven by severe shortages in the global surgical workforce. Task shifting is commonly implemented to expand the surgical workforce. A more complete understanding of the global distribution and use of surgical, obstetric, and anesthetic task shifting is lacking in the literature. We aimed to document the...

article

Improving Surgical Safety and Nontechnical Skills in Variable-Resource Contexts: A Novel Educational Curriculum

Yihan Lin, John W. Scott, Sojung Yi, Kathryn K. Taylor, more

Journal of Surgical Education > 2018 > 75 > 4 > 1014-1021

A substantial proportion of adverse intraoperative events are attributed to failures in nontechnical skills. To strengthen these skills and improve surgical safety, the Non-Technical Skills for Surgeons (NOTSS) taxonomy was developed as a common framework. The NOTSS taxonomy was adapted for low- and middle-income countries, where variable resources pose a significant challenge to safe surgery. The...

article

High Risk of Catastrophic Health Expenditure among Uninsured Emergency Surgery Patients in the United States

John W. Scott, Joaquim M. Havens, Nakul Raykar, John A. Rose, more

Journal of the American College of Surgeons > 2017 > 225 > 4(S1) > S118-S119

article

Intraoperative cholangiography during cholecystectomy among hospitalized medicare beneficiaries with non-neoplastic biliary disease

Elizabeth J. Lilley, John W. Scott, Wei Jiang, Anna Krasnova, more

The American Journal of Surgery > 2017 > 214 > 4 > 682-686

Prior studies of Medicare beneficiaries with both neoplastic and non-neoplastic indications for cholecystectomy demonstrated a reduced risk of common bile duct (CBD) injury when intraoperative cholangiography (IOC) was used. We sought to determine the association between IOC and CBD injury during inpatient cholecystectomy for non-neoplastic biliary disease and compare survival among those with or...

article

Hospice Is Associated with Decreased Healthcare Utilization for Medicare Beneficiaries Who Died after Trauma Admission

Elizabeth J. Lilley, John W. Scott, Daniel Sturgeon, Ali Salim, more

Journal of the American College of Surgeons > 2017 > 225 > 4(S1) > S94

article

Comparative assessment of in-hospital trauma mortality at a South African trauma center and matched patients treated in the United States

Richard T. Spence, John W. Scott, Adil Haider, Pradeep H. Navsaria, more

Surgery > 2017 > 162 > 3 > 620-627

The unacceptably high rate of death and disability due to injury in Sub-Saharan Africa is alarming. The objective of this work was to compare mortality rates between severely injured trauma patients at a high-volume trauma center in South Africa with matched patients in the United States.Clinical databases from the Groote Schuur Hospital for patients treated in Cape Town, South Africa and the American...

article

Fake Inhibitors: AMPK Activation Trumps Inhibition

Christopher G. Langendorf, John W. Scott, Bruce E. Kemp

Cell Chemical Biology > 2017 > 24 > 7 > 775-777

Protein kinase inhibitors have become increasingly important therapeutic drugs for the treatment of human diseases; however, resistance and off-target effects can limit their use. In this issue of Cell Chemical Biology, Ross et al. (2017) reveal a novel off-target mechanism where the Src kinase inhibitor SU6656 paradoxically primes AMPK for phosphorylation and activation by the upstream kinase LKB1.

article

Improving prehospital trauma care in Rwanda through continuous quality improvement: an interrupted time series analysis

John W. Scott, Jeanne D’Arc Nyinawankusi, Samuel Enumah, Rebecca Maine, more

Injury > 2017 > 48 > 7 > 1376-1381

Injury is a major cause of premature death and disability in East Africa, and high-quality pre-hospital care is essential for optimal trauma outcomes. The Rwandan pre-hospital emergency care service (SAMU) uses an electronic database to evaluate and optimize pre-hospital care through a continuous quality improvement programme (CQIP), beginning March 2014.The SAMU database was used to assess pre-hospital...

article

Erratum to: Development of a Unifying Target and Consensus Indicators for Global Surgical Systems Strengthening: Proposed by the Global Alliance for Surgery, Obstetric, Trauma, and Anaesthesia Care (The G4 Alliance)

Adil Haider, John W. Scott, Colin D. Gause, Mira Meheš, more

World Journal of Surgery > 2017 > 41 > 10 > 2423-2425

The online version of the original article can be found under doi: 10.1007/s00268-017-4028-1 .

article

Development of a Unifying Target and Consensus Indicators for Global Surgical Systems Strengthening: Proposed by the Global Alliance for Surgery, Obstetric, Trauma, and Anaesthesia Care (The G4 Alliance)

Adil Haider, John W. Scott, Colin D. Gause, Mira Meheš, more

World Journal of Surgery > 2017 > 41 > 10 > 2426-2434

After decades on the margins of primary health care, surgical and anaesthesia care is gaining increasing priority within the global development arena. The 2015 publications of the Disease Control Priorities third edition on Essential Surgery and the Lancet Commission on Global Surgery created a compelling evidenced-based argument for the fundamental role of surgery and anaesthesia within cost-effective...

article

Insurance status is associated with complex presentation among emergency general surgery patients

John W. Scott, Joaquim M. Havens, Lindsey L. Wolf, Cheryl K. Zogg, more

Surgery > 2017 > 161 > 2 > 320-328

The Affordable Care Act has the potential to significantly affect access to care for previously uninsured patients in need of emergency general surgical care. Our objective was to determine the relationship between insurance status and disease complexity at presentation among a national sample of emergency general surgical patients.Data from the National Emergency Department Sample from 2006–2009...

article

Epidemiology of injuries and outcomes among trauma patients receiving prehospital care at a tertiary teaching hospital in Kigali, Rwanda

Gabin Mbanjumucyo, Naomi George, Alexis Kearney, Naz Karim, more

African Journal of Emergency Medicine > 2016 > 6 > 4 > 191-197

Injury accounts for 9.6% of the global mortality burden, disproportionately affecting those living in low- and middle-income countries. In an effort to improve trauma care in Rwanda, the Ministry of Health developed a prehospital service, Service d’Aide Médicale Urgente (SAMU), and established an emergency medicine training program. However, little is known about patients receiving prehospital and...

article

Differential access to care: The role of age, insurance, and income on race/ethnicity-related disparities in adult perforated appendix admission rates

Cheryl K. Zogg, John W. Scott, Wei Jiang, Lindsey L. Wolf, more

Surgery > 2016 > 160 > 5 > 1145-1154

Differences in perforated appendix admission rates (PAAR) are an ambulatory-sensitive measure of access to care. While pediatric studies report disparities in PAAR, initial adult investigations suggest a lack of racial/ethnic inequity. The objectives of this study were to (1) assess for risk-adjusted, racial/ethnic differences in PAAR among adults on a national scale, (2) consider the extent to which...

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INFONA - science communication portal

Search results for: John W. Scott

Understanding the impacts of rural hospital closures: A scoping review

High‐risk surgery among Medicare beneficiaries living in health professional shortage areas

Patient adverse financial outcomes before and after COVID‐19 infection

Differences Between Emergency Department and Urgent Care Users for Low‐acuity Health Needs: A Public Opinion Analysis

Functional analysis of an R311C variant of Ca²⁺‐calmodulin‐dependent protein kinase kinase‐2 (CaMKK2) found as a de novo mutation in a patient with bipolar disorder

Ty-6, a major begomovirus resistance gene on chromosome 10, is effective against Tomato yellow leaf curl virus and Tomato mottle virus

The impact of individual physicians on outcomes after trauma: is it the system or the surgeon?

Global surgical, obstetric, and anesthetic task shifting: A systematic literature review

Improving Surgical Safety and Nontechnical Skills in Variable-Resource Contexts: A Novel Educational Curriculum

High Risk of Catastrophic Health Expenditure among Uninsured Emergency Surgery Patients in the United States

Intraoperative cholangiography during cholecystectomy among hospitalized medicare beneficiaries with non-neoplastic biliary disease

Hospice Is Associated with Decreased Healthcare Utilization for Medicare Beneficiaries Who Died after Trauma Admission

Comparative assessment of in-hospital trauma mortality at a South African trauma center and matched patients treated in the United States

Fake Inhibitors: AMPK Activation Trumps Inhibition

Improving prehospital trauma care in Rwanda through continuous quality improvement: an interrupted time series analysis

Erratum to: Development of a Unifying Target and Consensus Indicators for Global Surgical Systems Strengthening: Proposed by the Global Alliance for Surgery, Obstetric, Trauma, and Anaesthesia Care (The G4 Alliance)

Development of a Unifying Target and Consensus Indicators for Global Surgical Systems Strengthening: Proposed by the Global Alliance for Surgery, Obstetric, Trauma, and Anaesthesia Care (The G4 Alliance)

Insurance status is associated with complex presentation among emergency general surgery patients

Epidemiology of injuries and outcomes among trauma patients receiving prehospital care at a tertiary teaching hospital in Kigali, Rwanda

Differential access to care: The role of age, insurance, and income on race/ethnicity-related disparities in adult perforated appendix admission rates

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