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IL-7 receptor (IL-7R) plays critical roles in lymphocyte development by promoting survival and proliferation and by inducing V(D)J recombination in TCR and Ig loci. Here, we demonstrate that IL-7R-activated Stat5 binds to consensus motifs in the 5' regions of Jγ segments and induces germline transcripts. We also show that a constitutively active form of Stat5 restores V-J recombination of TCRγ genes...
In a previous study, we characterized prostanoid and thrombin receptors expressed on a megakaryoblastic cell line, MEG-01s (Blood 78, 2328-2336, 1991). In this study, we examines the mechanism of cross-talk between intracellular Ca 2+ ([Ca 2+ ] i ) and cAMP signalings through prostanoid and thrombin receptors. Addition of a thromboxane (TX)A 2 mimetic (U46619...
We generated interleukin-5 receptor α chain (IL-5Rα)- deficient (IL-5Rα -/- ) mice by gene targeting. The IL-5Rα -/- mice showed decreased numbers of B-1 cells concomitant with low serum concentrations of IgM and IgG3. They showed no IL-5-induced enhancement of B cell responses to T-independent antigens. The number of αβ T cell receptor-positive thymocytes tended...
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