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Aims
Multiple evidence has indicated that myelin injury is common in Alzheimer's disease (AD). However, whether myelin injury is an early event in AD and the relationship between it and cognitive function is still elusive.
Methods
Spatial memory of 5XFAD mice was determined by Morris water maze at 1 and 3 months old. Meanwhile, the deposition of Aβ, the expression of myelin basic protein (MBP),...
Since the computer hardware power has been improved, neural networks have been widely applied in different fields. However, to the best of our knowledge, the idea of coding spatial information for Alzheimer's disease classification in the regularization neural network context is still new. This motivation has led us to propose a spatial regularization approach for neural network and apply it to structural...
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