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We have shown previously in the rat that biglycan, a recently discovered chondroitin sulfate proteoglycan, has neurotrophic effects which are mediated by its chondroitin/dermatan sulfate chains. Here we report that biglycan has neurochemical effects when injected into the nucleus basalis magnocellularis of the ventral pallidum, a site of dense cholinergic cell bodies. The effects on the cholinergic...
Based on their rearing response to a novel open field, male Wistar rats were divided into two sub-groups with either high or low behavioural activity (high rearings, versus low rearings). These sub-groups were repeatedly exposed to the same open field and tested for behavioural habituation. Since we previously found neurochemical evidence for different cholinergic reactivities in such high rearing...
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