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Six homologous derivatives (N-butyl 3a, hexyl 3b, octyl 3c, decyl 3d, tetradecyl 3e and stearyl 3f) of β-valienamine were synthesized. All have been shown to be potent and specific inhibitors of β-glucocerebrosidase, and to have no potency against glucosylceramide synthase (mouse liver microsomes). Among them, the N-octyl derivative possesses the strongest activity (IC 50 3 10 ...
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