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We have examined the effects of intrathecal (i.t.) human calcitonin gene-related peptide (hCGRP) and its C-terminal fragment hCGRP(8-37), a proposed CGRP antagonist, on the flexor reflex in decerebrate, spinalized, unanesthetized rats. I.t. hCGRP at 26 pmol caused a moderate facilitation of the reflex which was not antagonized by hCGRP(8-37) at doses ranging from 26 pmol to 5.2 nmol. Furthermore,...
The effects of subcutaneous (s.c.) administration of formalin or carrageenan to the rat hindpaw on the ipsilateral nociceptive flexor reflex was examined in decerebrate, spinalized, unanesthetized rats in order to assess the development of spinal hyperexcitability following peripheral inflammation. Carrageenan induced a weak and brief EMG discharge at the time of injection, followed by a gradual...
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