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Nuclear factor-kappaB (NF- κ B) is a pleiotropic oxidant-sensitive transcription factor that is present in the cytosol in an inactive form complexed to an inhibitory kappaB (I κ B) monomer. Various stimuli, including ischemia, hypoxia, free radicals, cytokines, and lipopolysaccharide (LPS), activate NF- κ B by inducing phosphorylation of I κ B. Phosphorylation of serine residues at positions 32 and...
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