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The most widely known blood groups, ABO and RhD, have been extensively observed as having strong antibody-antigen interactions during blood typing. However, not all interactions show the same binding affinity. The Duffy blood group system, where Fya and Fyb antigens are the most clinically significant, are only available with an IgG antibody structure, and display weak binding interactions. While...
The accurate and reliable typing of blood groups is essential prior to blood transfusion. While current blood typing methods are well established, results are subjective and heavily reliant on analysis by trained personnel. Techniques for quantifying blood group antibody–antigen interactions are also very limited. Many biosensing systems rely on surface plasmon resonance (SPR) detection to quantify...
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