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HEK 293 cells stably expressing human melanocortin-3 receptor (MC3R) were exposed to melanocortin receptor agonist, NDP-MSH (10 −10 –10 −6 M). ERK1/2 was phosphorylated in a dose-dependent manner with an EC 50 of 3.3±1.5×10 −9 M, similar to the IC 50 of NDP-MSH binding to the MC3R. ERK1/2 phosphorylation was blocked by the melanocortin receptor...
The melanocortin-4 receptor (MC4R) is a seven transmembrane member of the melanocortin receptor family. The GT1-1 cell line exhibits endogenous expression of MC4R. In this study, GT1-1 cells were used to study MC4R signaling pathways and to examine the effects of melanocortin receptor agonist NDP-MSH on apoptosis. MC4R mRNA expression was demonstrated by RT-PCR. Functional melanocortin receptor expression...
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