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Recent reports demonstrate that the activation and interaction of the protease calpain (CP) and the protein phosphatase calcineurin (CN) are elevated in the late stages of Alzheimer’s disease (AD). However, the extent to which CPs and CN interact during earlier stages of disease progression remains unknown. Here, we investigated CP and CN protein levels in cytosolic, nuclear, and membrane fractions...
Amnestic mild cognitive impairment (MCI) appears to be a very early stage of Alzheimer’s disease (AD). The amyloid-β peptide (Aβ) is believed to be a possible substrate for AD, but little is currently known about Aβ alterations in MCI and how these changes compare to later stages of disease. In the present study Aβ was differentially extracted from the brains of age-matched control, MCI, and AD cases...
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