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We recently proposed a bias correction approach to evaluate accurate estimation of the odds ratio (OR) of genetic variants associated with a secondary phenotype, in which the secondary phenotype is associated with the primary disease, based on the original case‐control data collected for the purpose of studying the primary disease. As reported in this communication, we further investigated the type...
Variance components analysis provides an efficient method for performing linkage analysis for quantitative traits. However, power and type 1 error of variance components–based likelihood ratio testing may be affected when phenotypic data are nonnormally distributed (especially with high values of kurtosis) and there is moderate to high correlation among the siblings. Winsorization can reduce the effect...
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