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Achilles tendon injuries are common clinical problems for athletes, especially in runners. Several studies indicate that Achilles tendinopathy is accompanied with neovascularization or hypervascularity; thus, assessments of vascularity are important when assessing inflammation changes in tendon injuries. Photoacoustic imaging, taking the advantages of good ultrasonic resolution and high optical absorption...
In this study, we propose a radial-modulation chirp imaging method for contrast detection with high frequency ultrasound. This method detects microbubbles by extracting and then selectively compressing the radial-modulated chirp component of the response. The amplitude of the imaging chirp signal will be radial modulated at the resonance frequency due to the high-amplitude oscillation of the microbubble...
Focused ultrasound thermal therapy relies on temperature monitoring for treatment guidance and assurance of targeting and dose control; a potential approach to achieve these is ultrasonic temperature estimation. The approach used currently involves the detection of echo time shifts based on cross-correlation processing from the segmented radio-frequency (RF) data. In this study, we propose a novel...
Chronic degenerative Achilles tendinopathy (tendonitis) is a common clinical problem and its aetiology remains in part unexplained. For the treatment of Achilles tendinopathy, there were a lot of modalities including medication, physical agents, physiotherapy, and exercise. However, how to evaluate the effects of current therapeutic modalities and study the therapeutic mechanism in vivo remains a...
An in vivo backward-mode photoacoustic microscope was recently developed that employs a high frequency, broadband, large numerical aperture (NA) focused ultrasonic transducer to provide high resolution and high sensitivity. However, out of the focus region, the limited depth of focus deteriorated the image quality significantly. Based on a virtual-detector concept, we devised and implemented a synthetic...
Because of the overwhelming scattering of light in biological tissues, the spatial resolution and imaging depth of conventional fluorescent imaging is unsatisfactory. Therefore, we present a dual modality imaging technique by combining fluorescence imaging with high-resolution noninvasive photoacoustic tomography (PAT) for the study of an animal tumor model. PAT provides high-resolution structural...
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