Search results for: Judy C. Boughey

Items from 1 to 20 out of 165 results

article

Primary tumor resection in patients with stage IV breast cancer: 10‐year experience

Malke Asaad, Jennifer A. Yonkus, Tanya L. Hoskin, Tina J. Hieken, more

The Breast Journal > 27 > 12 > 863 - 871

The role of surgery in the management of stage IV breast cancer is controversial. Existing studies in Stage IV breast cancer have not closely evaluated the role of patient response to induction systemic therapy (IST) in its relationship to survival outcomes. We identified all patients with a diagnosis of de novo stage IV breast cancer who underwent surgery of their primary tumor from January 2008...

article

Breast cancer—The catalyst of contemporary trials design

Zahraa Al‐Hilli, Anna Weiss, Ava Armani, Judy C Boughey, more

Journal of Surgical Oncology > 125 > 1 > 7 - 16

Surgical trials in breast cancer have catalyzed contemporary trial design for solid organ cancers and are a prime example of surgeons taking the lead in clinical trial design. Surgeons have lead trials that have improved patient outcomes and quality of life without sacrificing oncologic safety. We have evolved from radical mastectomy to breast conservation and sentinel node biopsy. Contemporary trial...

article

Reply to On the proportion of male breast cancer among all breast cancers

Siddhartha Yadav, Dhauna Karam, Irbaz Bin Riaz, Hao Xie, more

Cancer > 126 > 9 > 2034 - 2035

article

Integrated cancer networks improve compliance with national guidelines and outcomes for resectable gastric cancer

Cornelius A. Thiels, Kristine T. Hanson, Elizabeth B. Habermann, Judy C. Boughey, more

Cancer > 126 > 6 > 1283 - 1294

Background National Comprehensive Cancer Network (NCCN) guidelines recommend accurate clinical staging, perioperative therapy, and complete lymphadenectomy for patients with stage II to III gastric cancer. However, national compliance remains low. It was hypothesized that integrated cancer networks might improve compliance and outcomes within the community. Methods Patients with stage II to III...

article

Male breast cancer in the United States: Treatment patterns and prognostic factors in the 21st century

Siddhartha Yadav, Dhauna Karam, Irbaz Bin Riaz, Hao Xie, more

Cancer > 126 > 1 > 26 - 36

Background Male breast cancer (MBC) is a rare disease for which there is limited understanding of treatment patterns and prognostic factors. Methods Men with TNM stage I to stage III breast cancer diagnosed between 2004 and 2014 in the National Cancer Data Base were included. Trends in treatment modalities were described using the average annual percentage change (AAPC) and estimated using Joinpoint...

article

Identifying Residual Nodal Disease in Sentinel Lymph Node Surgery After Neoadjuvant Chemotherapy for Breast Cancer

Judy C. Boughey

Annals of Surgical Oncology > 2019 > 26 > 12 > 3794-3797

article

Adolescents and Young Adults with Breast Cancer have More Aggressive Disease and Treatment Than Patients in Their Forties

Brittany L. Murphy, Courtney N. Day, Tanya L. Hoskin, Elizabeth B. Habermann, more

Annals of Surgical Oncology > 2019 > 26 > 12 > 3920-3930

Background Adolescents and young adults (AYAs; age < 40 years) account for less than 2% of breast cancer patients. Therefore, little is known about the tumor characteristics and care provided to AYA patients. This study sought to describe demographic, tumor, and treatment variables among AYA patients. Methods The study identified patients ages 15 to 49 years with breast cancer between 2010 and...

article

Outcomes of > 1300 Nipple-Sparing Mastectomies with Immediate Reconstruction: The Impact of Expanding Indications on Complications

Whitney A. Young, Amy C. Degnim, Tanya L. Hoskin, James W. Jakub, more

Annals of Surgical Oncology > 2019 > 26 > 10 > 3115-3123

Background The enhanced esthetics and demonstrated oncologic safety of nipple-sparing mastectomy (NSM) in selected patients have resulted in increased rates among patients with locally advanced breast cancer and/or additional risk factors (obesity, prior radiation, surgery). Limited data exist on complication and reconstruction success rates in a contemporary patient cohort with expanded indications...

article

Consensus Guidelines on Genetic` Testing for Hereditary Breast Cancer from the American Society of Breast Surgeons

Eric R. Manahan, Henry M. Kuerer, Molly Sebastian, Kevin S. Hughes, more

Annals of Surgical Oncology > 2019 > 26 > 10 > 3025-3031

Background The purpose of this consensus guideline is to outline recommendations for genetic testing that medical professionals can use to assess hereditary risk for breast cancer. Methods Literature review included large datasets, basic and clinical science publications, and recent updated national guidelines. Genetic testing to assess hereditary risk of cancer is a complex, broad, and dynamic...

article

Effect of Surgery Type on Time to Adjuvant Chemotherapy and Impact of Delay on Breast Cancer Survival: A National Cancer Database Analysis

Amanda R. Kupstas, Tanya L. Hoskin, Courtney N. Day, Elizabeth B. Habermann, more

Annals of Surgical Oncology > 2019 > 26 > 10 > 3240-3249

Background Timeliness of care is emerging as a quality indicator for breast cancer care. We sought to evaluate the impact of surgical treatment type on time to adjuvant chemotherapy and impact of treatment delay on survival. Methods Patients with stage I–III breast cancer treated with both surgery and adjuvant chemotherapy from 2010 to 2014 were identified from the National Cancer Database (NCDB)...

article

The novel function of tumor protein D54 in regulating pyruvate dehydrogenase and metformin cytotoxicity in breast cancer

Yongxian Zhuang, Reynold C. Ly, Carleigh V. Frazier, Jia Yu, more

Cancer & Metabolism > 2019 > 7 > 1 > 1-15

Background The role of tumor protein D54 in breast cancer has not been studied and its function in breast cancer remains unclear. In our previous pharmacogenomic studies using lymphoblastoid cell line (LCL), this protein has been identified to affect metformin response. Although metformin has been widely studied as a prophylactic and chemotherapeutic drug, there is still a lack of biomarkers predicting...

article

Intermediate and long‐term outcomes of fibroadenoma excision in adolescent and young adult patients

Asma Javed, Sarah M. Jenkins, Brian Labow, Judy C. Boughey, more

The Breast Journal > 25 > 1 > 91 - 95

Fibroadenomas are benign breast masses that often occur in adolescence and young adulthood. Primary management options include observation or surgical excision, but little is known about long‐term outcomes after fibroadenoma excision in adolescents. In the present study, we reviewed the medical records of females aged 13‐35 years who underwent fibroadenoma excision at our institution from 1986 through...

article

Lessons Learned Regarding Missing Clinical Stage in the National Cancer Database

Tanya L. Hoskin, Judy C. Boughey, Courtney N. Day, Elizabeth B. Habermann

Annals of Surgical Oncology > 2019 > 26 > 3 > 739-745

Background The National Cancer Database (NCDB) is a valuable resource for studying national cancer treatment patterns. However, data abstraction rules from 2004 to 2007 resulted in missing clinical stage for a high percentage of cases. We investigated how this missingness can bias results in breast cancer studies including patients treated with neoadjuvant chemotherapy (NAC). Methods The impact...

article

ASO Author Reflections: Changes in Use of Neoadjuvant Chemotherapy Over Time—Highest Rates of Use Now in Triple-Negative and HER2+ Disease

Brittany L. Murphy, Judy C. Boughey

Annals of Surgical Oncology > 2018 > 25 > 3 > 695-696

ASO Author Reflections is a brief invited commentary on the article, “Neoadjuvant Chemotherapy Use in Breast Cancer is Greatest in Excellent Responders: Triple-Negative and HER2+ Subtypes.” Ann Surg Oncol. 2018;25:2241–2248.

article

ASO Author Reflections: Rate of Axillary Lymph Node Dissection has Decreased in Patients Treated with Neoadjuvant Systemic Therapy

Toan T. Nguyen, Judy C. Boughey

Annals of Surgical Oncology > 2018 > 25 > 3 > 693-694

ASO Author Reflections is a brief invited commentary on the article, “Decreasing Use of Axillary Dissection in Node-Positive Breast Cancer Patients Treated with Neoadjuvant Chemotherapy.” Ann Surg Oncol. 2018;25:2596–2602.

article

A contemporary review of male breast cancer: current evidence and unanswered questions

Roberto A. Leon-Ferre, Karthik V. Giridhar, Tina J. Hieken, Robert W. Mutter, more

Cancer and Metastasis Reviews > 2018 > 37 > 4 > 599-614

Male breast cancer is rare, accounting for 1% of all breast cancer diagnoses in the USA. Because of its rarity, most major breast cancer trials have included only female patients. This has resulted in limited prospective data to guide the clinical management of men with breast cancer. As a result, treatment decisions are typically extrapolated from data generated in female patients. This approach...

article

Influence of Biologic Subtype of Inflammatory Breast Cancer on Response to Neoadjuvant Therapy and Cancer Outcomes

Tina J. Hieken, Brittany L. Murphy, Judy C. Boughey, Amy C. Degnim, more

Clinical Breast Cancer > 2018 > 18 > 4 > e501-e506

Few data exist on the influence of tumor biologic subtype on treatment response and outcomes for inflammatory breast cancer (IBC). We examined a contemporary cohort of IBC patients treated with current targeted systemic therapies, selected on the basis of tumor biologic subtype, to evaluate pathologic treatment response and cancer outcomes across biologic subtypes.We studied 57 clinical stage T4dM0...

article

HGT-ID: an efficient and sensitive workflow to detect human-viral insertion sites using next-generation sequencing data

Saurabh Baheti, Xiaojia Tang, Daniel R. O’Brien, Nicholas Chia, more

BMC Bioinformatics > 2018 > 19 > 1 > 1-11

Background Transfer of genetic material from microbes or viruses into the host genome is known as horizontal gene transfer (HGT). The integration of viruses into the human genome is associated with multiple cancers, and these can now be detected using next-generation sequencing methods such as whole genome sequencing and RNA-sequencing. Results We designed a novel computational workflow, HGT-ID,...

article

The Feasibility of Breast-Conserving Surgery for Multiple Ipsilateral Breast Cancer: An Initial Report from ACOSOG Z11102 (Alliance) Trial

Kari M. Rosenkranz, Karla Ballman, Linda McCall, Charlotte Kubicky, more

Annals of Surgical Oncology > 2018 > 25 > 10 > 2858-2866

Background Historically, multiple ipsilateral breast cancer (MIBC) has been a contraindication to breast-conserving therapy (BCT). We report the feasibility of BCT in MIBC from the ACOSOG Z11102 trial [Alliance], a single arm noninferiority trial of BCT for women with two or three sites of malignancy in the ipsilateral breast. Methods Women who enrolled preoperatively in ACOSOG Z11102 were evaluated...

article

Lymphedema symptoms and limb measurement changes in breast cancer survivors treated with neoadjuvant chemotherapy and axillary dissection: results of American College of Surgeons Oncology Group (ACOSOG) Z1071 (Alliance) substudy

Jane M. Armer, Karla V. Ballman, Linda McCall, Nathan C. Armer, more

Supportive Care in Cancer > 2019 > 27 > 2 > 495-503

Purpose Lymphedema is a potential complication of breast cancer treatment. This longitudinal substudy aimed to prospectively assess arm measurements and symptoms following neoadjuvant chemotherapy and axillary dissection in the ACOSOG/Alliance Z1071 trial to characterize the optimal approach to define lymphedema. Methods Z1071 enrolled patients with cT0-4, N1-2, M0 disease treated with neoadjuvant...

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INFONA - science communication portal

Search results for: Judy C. Boughey

Primary tumor resection in patients with stage IV breast cancer: 10‐year experience

Breast cancer—The catalyst of contemporary trials design

Reply to On the proportion of male breast cancer among all breast cancers

Integrated cancer networks improve compliance with national guidelines and outcomes for resectable gastric cancer

Male breast cancer in the United States: Treatment patterns and prognostic factors in the 21st century

Identifying Residual Nodal Disease in Sentinel Lymph Node Surgery After Neoadjuvant Chemotherapy for Breast Cancer

Adolescents and Young Adults with Breast Cancer have More Aggressive Disease and Treatment Than Patients in Their Forties

Outcomes of > 1300 Nipple-Sparing Mastectomies with Immediate Reconstruction: The Impact of Expanding Indications on Complications

Consensus Guidelines on Genetic` Testing for Hereditary Breast Cancer from the American Society of Breast Surgeons

Effect of Surgery Type on Time to Adjuvant Chemotherapy and Impact of Delay on Breast Cancer Survival: A National Cancer Database Analysis

The novel function of tumor protein D54 in regulating pyruvate dehydrogenase and metformin cytotoxicity in breast cancer

Intermediate and long‐term outcomes of fibroadenoma excision in adolescent and young adult patients

Lessons Learned Regarding Missing Clinical Stage in the National Cancer Database

ASO Author Reflections: Changes in Use of Neoadjuvant Chemotherapy Over Time—Highest Rates of Use Now in Triple-Negative and HER2+ Disease

ASO Author Reflections: Rate of Axillary Lymph Node Dissection has Decreased in Patients Treated with Neoadjuvant Systemic Therapy

A contemporary review of male breast cancer: current evidence and unanswered questions

Influence of Biologic Subtype of Inflammatory Breast Cancer on Response to Neoadjuvant Therapy and Cancer Outcomes

HGT-ID: an efficient and sensitive workflow to detect human-viral insertion sites using next-generation sequencing data

The Feasibility of Breast-Conserving Surgery for Multiple Ipsilateral Breast Cancer: An Initial Report from ACOSOG Z11102 (Alliance) Trial

Lymphedema symptoms and limb measurement changes in breast cancer survivors treated with neoadjuvant chemotherapy and axillary dissection: results of American College of Surgeons Oncology Group (ACOSOG) Z1071 (Alliance) substudy

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